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Pediatric Low-Grade Gliomas

Collins, Kelly L. and Pollack, Ian F. (2020) Pediatric Low-Grade Gliomas. Cancers, 12 (5). p. 1152. ISSN 2072-6694

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Brain tumors constitute the largest source of oncologic mortality in children and low-grade gliomas are among most common pediatric central nervous system tumors. Pediatric low-grade gliomas differ from their counterparts in the adult population in their histopathology, genetics, and standard of care. Over the past decade, an increasingly detailed understanding of the molecular and genetic characteristics of pediatric brain tumors led to tailored therapy directed by integrated phenotypic and genotypic parameters and the availability of an increasing array of molecular-directed therapies. Advances in neuroimaging, conformal radiation therapy, and conventional chemotherapy further improved treatment outcomes. This article reviews the current classification of pediatric low-grade gliomas, their histopathologic and radiographic features, state-of-the-art surgical and adjuvant therapies, and emerging therapies currently under study in clinical trials.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Collins, Kelly L.kec205@pitt.edukec205
Pollack, Ian F.ipollack@pitt.eduipollack
Date: 4 May 2020
Date Type: Publication
Journal or Publication Title: Cancers
Volume: 12
Number: 5
Publisher: MDPI AG
Page Range: p. 1152
DOI or Unique Handle: 10.3390/cancers12051152
Schools and Programs: School of Medicine > Neurological Surgery
Refereed: Yes
Uncontrolled Keywords: pediatric low-grade glioma, pilocytic astrocytoma, diffuse astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, neuroepithelial tumor
ISSN: 2072-6694
Official URL:
Article Type: Review
Date Deposited: 11 Jun 2021 19:17
Last Modified: 11 Jun 2021 19:17


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