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Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights

Ye, Pengfei and Xi, Yue and Huang, Zhiying and Xu, Pengfei (2020) Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights. Cancers, 12 (6). p. 1408. ISSN 2072-6694

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The incidence of obesity and colorectal cancer (CRC) has risen rapidly in recent decades. More than 650 million obese and 2 billion overweight individuals are currently living in the world. CRC is the third most common cancer. Obesity is regarded as one of the key environmental risk factors for the pathogenesis of CRC. In the present review, we mainly focus on the epidemiology of obesity and CRC in the world, the United States, and China. We also summarize the molecular mechanisms linking obesity to CRC in different aspects, including nutriology, adipokines and hormones, inflammation, gut microbiota, and bile acids. The unmet medical needs for obesity-related CRC are still remarkable. Understanding the molecular basis of these associations will help develop novel therapeutic targets and approaches for the treatment of obesity-related CRC.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Ye, Pengfei
Xi, Yueyux42@pitt.eduyux42
Huang, Zhiying
Xu, Pengfeipex9@pitt.edupex90000-0001-6854-6040
Date: 26 May 2020
Date Type: Publication
Journal or Publication Title: Cancers
Volume: 12
Number: 6
Publisher: MDPI AG
Page Range: p. 1408
DOI or Unique Handle: 10.3390/cancers12061408
Schools and Programs: School of Pharmacy > Pharmaceutical Sciences
Refereed: Yes
Uncontrolled Keywords: obesity, colorectal cancer, epidemiology, hormones, inflammation, gut microbiota
ISSN: 2072-6694
Official URL:
Article Type: Review
Date Deposited: 14 Jun 2021 18:56
Last Modified: 14 Jun 2021 18:56


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