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PPAR-Mediated Toxicology and Applied Pharmacology

Xi, Yue and Zhang, Yunhui and Zhu, Sirui and Luo, Yuping and Xu, Pengfei and Huang, Zhiying (2020) PPAR-Mediated Toxicology and Applied Pharmacology. Cells, 9 (2). p. 352. ISSN 2073-4409

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Abstract

Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, attract wide attention as promising therapeutic targets for the treatment of multiple diseases, and their target selective ligands were also intensively developed for pharmacological agents such as the approved drugs fibrates and thiazolidinediones (TZDs). Despite their potent pharmacological activities, PPARs are reported to be involved in agent- and pollutant-induced multiple organ toxicity or protective effects against toxicity. A better understanding of the protective and the detrimental role of PPARs will help to preserve efficacy of the PPAR modulators but diminish adverse effects. The present review summarizes and critiques current findings related to PPAR-mediated types of toxicity and protective effects against toxicity for a systematic understanding of PPARs in toxicology and applied pharmacology.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Xi, Yueyux42@pitt.eduyux42
Zhang, Yunhui
Zhu, Sirui
Luo, Yuping
Xu, Pengfeipex9@pitt.edupex9
Huang, Zhiying
Date: 3 February 2020
Date Type: Publication
Journal or Publication Title: Cells
Volume: 9
Number: 2
Publisher: MDPI AG
Page Range: p. 352
DOI or Unique Handle: 10.3390/cells9020352
Schools and Programs: School of Pharmacy > Pharmaceutical Sciences
Refereed: Yes
Uncontrolled Keywords: ppars, toxicology, pharmacology, ligand
ISSN: 2073-4409
Official URL: http://dx.doi.org/10.3390/cells9020352
Funders: National Natural Science Foundation of China, General Projects in the Natural Science Foundation of Guangdong Province, National Engineering and Technology Research Center for New drug Druggability Evaluation
Article Type: Review
Date Deposited: 29 Jun 2021 18:39
Last Modified: 29 Jun 2021 18:39
URI: http://d-scholarship.pitt.edu/id/eprint/41313

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