Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Memory CD4+ T Cells in Immunity and Autoimmune Diseases

Raphael, Itay and Joern, Rachel R. and Forsthuber, Thomas G. (2020) Memory CD4+ T Cells in Immunity and Autoimmune Diseases. Cells, 9 (3). p. 531. ISSN 2073-4409 (In Press)

Published Version

Download (1MB) | Preview


CD4+ T helper (Th) cells play central roles in immunity in health and disease. While much is known about the effector function of Th cells in combating pathogens and promoting autoimmune diseases, the roles and biology of memory CD4+ Th cells are complex and less well understood. In human autoimmune diseases such as multiple sclerosis (MS), there is a critical need to better understand the function and biology of memory T cells. In this review article we summarize current concepts in the field of CD4+ T cell memory, including natural history, developmental pathways, subsets, and functions. Furthermore, we discuss advancements in the field of the newly-described CD4+ tissue-resident memory T cells and of CD4+ memory T cells in autoimmune diseases, two major areas of important unresolved questions in need of answering to advance new vaccine design and development of novel treatments for CD4+ T cell-mediated autoimmune diseases.


Social Networking:
Share |


Item Type: Article
Status: In Press
CreatorsEmailPitt UsernameORCID
Joern, Rachel R.
Forsthuber, Thomas G.
Date: 25 February 2020
Date Type: Publication
Journal or Publication Title: Cells
Volume: 9
Number: 3
Publisher: MDPI AG
Page Range: p. 531
DOI or Unique Handle: 10.3390/cells9030531
Schools and Programs: School of Medicine > Neurological Surgery
Refereed: Yes
Uncontrolled Keywords: CD4+ T cells; memory T cells; autoimmune disease; effector memory T cell; central memory T cell; tissue-resident T cell
ISSN: 2073-4409
Official URL:
Funders: National Institute of Health, National Multiple Sclerosis Society
Article Type: Panel
Date Deposited: 29 Jun 2021 18:45
Last Modified: 29 Jun 2021 18:45


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item