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New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation

Marchetti, Alexander L. and Guo, Haitao (2020) New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation. Cells, 9 (11). p. 2430. ISSN 2073-4409

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The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease. Being able to target and eliminate cccDNA is the end goal for a genuine cure for HBV. Yet how HBV cccDNA is formed from the viral genomic relaxed circular DNA (rcDNA) and by what host factors had been long-standing research questions. It is generally acknowledged that HBV hijacks cellular functions to turn the open circular DNA conformation of rcDNA into cccDNA through DNA repair mechanisms. With great efforts from the HBV research community, there have been several recent leaps in our understanding of cccDNA formation. It is our goal in this review to analyze the recent reports showing evidence of cellular factor’s involvement in the molecular pathway of cccDNA biosynthesis.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Marchetti, Alexander L.
Centers: Other Centers, Institutes, Offices, or Units > Hillman Cancer Center
Date: 6 November 2020
Date Type: Publication
Journal or Publication Title: Cells
Volume: 9
Number: 11
Publisher: MDPI AG
Page Range: p. 2430
DOI or Unique Handle: 10.3390/cells9112430
Schools and Programs: School of Medicine > Microbiology and Molecular Genetics
Refereed: Yes
Uncontrolled Keywords: hepatitis B virus, replication, covalently closed circular DNA, DNA repair
ISSN: 2073-4409
Official URL:
Funders: U.S. National Institutes of Health
Article Type: Review
Date Deposited: 28 Jun 2021 19:11
Last Modified: 28 Jun 2021 19:11


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