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Rapid growth of an intact human liver transplanted into a recipient larger than the donor

Van Thiel, DH and Gavaler, JS and Kam, I and Francavilla, A and Polimeno, L and Schade, RR and Smith, J and Diven, W and Penkrot, RJ and Starzl, TE (1987) Rapid growth of an intact human liver transplanted into a recipient larger than the donor. Gastroenterology, 93 (6). 1414 - 1419. ISSN 0016-5085

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Two individuals undergoing orthotopic hepatic transplantation received livers from donors who were on average 10 kg smaller than themselves based on recipient ideal body weight. As a result, the donor livers in these 2 cases were 29%-59% smaller than would be expected had the donor liver and recipient been matched ideally. The liver grafts in the recipients steadily increased in size, as determined by serial computed tomography scanning, to achieve new volumes consistent with those that would have been expected in a normal individual of the recipient's size, sex, and age. Fasting plasma levels of amino acids, glucagon, insulin, and standard liver injury tests were monitored to determine which measure best reflected the changes observed in the size of the grafts over time. No relationship between the changes observed in any of these parameters and hepatic growth was apparent. In both cases, the liver increased in volume at a rate of ~70 ml/day. These data demonstrate that a small-for-size liver transplanted into a larger recipient increases in size at a rate of ~70 ml/day until it achieves a liver volume consistent with that expected given the recipient's size, age, and sex. © 1987.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Van Thiel, DH
Gavaler, JS
Kam, I
Francavilla, A
Polimeno, L
Schade, RR
Smith, J
Diven, W
Penkrot, RJ
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1987
Date Type: Publication
Journal or Publication Title: Gastroenterology
Volume: 93
Number: 6
Page Range: 1414 - 1419
DOI or Unique Handle: 10.1016/0016-5085(87)90274-5
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0016-5085
Other ID: uls-drl:31735062119445, Starzl CV No. 750
Date Deposited: 08 Apr 2010 17:12
Last Modified: 02 Feb 2019 13:58


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