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Adenoviral Infections in Pediatric Liver Transplant Recipients

Koneru, B and Jaffe, R and Esquivel, CO and Kunz, R and Todo, S and Iwatsuki, S and Starzl, TE (1987) Adenoviral Infections in Pediatric Liver Transplant Recipients. JAMA: The Journal of the American Medical Association, 258 (4). 489 - 492. ISSN 0098-7484

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Over a 51/2-year period, 22 of 262 children receiving liver transplants developed adenoviral infections. Five had adenoviral hepatitis in the allograft, caused by serotype 5. All five were treated for rejection, either just before or at the time of infection. Liver biopsy specimens had characteristic histological appearance, and diagnosis of adenoviral infection was confirmed with monoclonal antiadenoviral antibodies, electron microscopy, and by culture of liver tissue. In the remaining 17 patients, adenovirus was isolated from urine, stool, throat secretions, and/or blood samples, but none had any detectable visceral infection. Serotypes 1 and 2 predominated, similar to children not receiving transplants during the same time period. Three of the patients with hepatitis are alive and well; two died of liver failure. Adenoviral hepatitis did not recur in the second allograft of a patient who underwent retransplantation for combined rejection and adenoviral hepatitis, and appears, therefore, not to be a contraindication to retransplantation when liver failure ensues. © 1987, American Medical Association. All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Koneru, B
Jaffe, R
Esquivel, CO
Kunz, R
Todo, S
Iwatsuki, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 24 July 1987
Date Type: Publication
Journal or Publication Title: JAMA: The Journal of the American Medical Association
Volume: 258
Number: 4
Page Range: 489 - 492
DOI or Unique Handle: 10.1001/jama.1987.03400040087027
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0098-7484
Other ID: uls-drl:31735062119478, Starzl CV No. 753
Date Deposited: 08 Apr 2010 17:12
Last Modified: 29 Jan 2019 15:55


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