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New Approaches toward the Syntheses of Hsp70 Agonists

NGO, LINH KHAI (2021) New Approaches toward the Syntheses of Hsp70 Agonists. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

The thesis presented new syntheses of Hsp70 agonists. Chapter 1 overviewed neurological disorders, the current therapeutic and diagnostic approaches for the diseases. Chapter 2 touched upon heat shock protein (Hsp) and the molecular chaperone, Hsp70. Chapter 3, 4, and 5 presented efforts in the design for more potent analogues than MAL1-271, a Hsp70 agonist. While Chapter 3 showcased the synthesis of the new dihydropyrimidinone (DHPM) molecules, Chapter 4 focused on the preparation for the thiadiazine analogues. All of these analogues were evaluated in a cellular Huntington’s disease model in the laboratory of Prof. J. Brodsky at the University of Pittsburgh and resulted in several lead structures. Chapter 5 reviewed the preliminary results on a synthesis of thiadiazine-containing macrocycles. Initial explorations involved the use of ruthenium-based catalysts to construct a 10-membered ring

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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
NGO, LINH KHAILKN9@PITT.EDU0000-0003-3268-4323
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairWIPF, PETERpwipf@pitt.edu
Committee MemberWANG, YIMINGym.wang@pitt.edu
Committee MemberISLAM, KABIRULkai27@pitt.edu
Date: 8 October 2021
Date Type: Publication
Defense Date: 7 May 2021
Approval Date: 8 October 2021
Submission Date: 29 July 2021
Access Restriction: 1 year -- Restrict access to University of Pittsburgh for a period of 1 year.
Number of Pages: 107
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: HSP70 BIGINELLI THIADIAZINE
Date Deposited: 08 Oct 2022 05:00
Last Modified: 19 May 2023 14:03
URI: http://d-scholarship.pitt.edu/id/eprint/41522

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