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Evidence that host size determines liver size: Studies in dogs receiving orthotopic liver transplants

Kam, I and Lynch, S and Svanas, G and Todo, S and Polimeno, L and Francavilla, A and Penkrot, RJ and Takaya, S and Ericzon, BG and Starzl, TE and Van Thiel, DH (1987) Evidence that host size determines liver size: Studies in dogs receiving orthotopic liver transplants. Hepatology, 7 (2). 362 - 366. ISSN 0270-9139

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Abstract

Orthotopic liver transplantation was performed in two groups of dogs; Group I animals consisted of large dogs that served as recipients of livers obtained from smaller dogs while Group II animals consisted of dogs that received liver from donor dogs of nearly the same size. The small‐for‐size livers transplanted into the Group I dogs rapidly increased in size over the course of 2 weeks until they achieved a size equal to that originally present in the larger recipient dogs. In contrast, the livers transplanted into dogs of the same size as the donors underwent some degree of atrophy. In both groups of animals, plasma levels of insulin and glucagon and hepatic (graft) activities of thymidine kinase and ornithine decarboxylase were followed serially. The only difference between the two groups of animals for these measures was that the ornithine decarboxylase activity rose to a greater degree in the liver that underwent graft enlargement. These data suggest that recipient size determines, at least in part, liver graft size once it is transplanted. These data also suggest that of the parameters followed, only ornithine decarboxylase activity parallels the finding of growth of the transplanted liver. Copyright © 1987 American Association for the Study of Liver Diseases


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kam, I
Lynch, S
Svanas, G
Todo, S
Polimeno, L
Francavilla, A
Penkrot, RJ
Takaya, S
Ericzon, BG
Starzl, TEtes11@pitt.eduTES11
Van Thiel, DH
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1987
Date Type: Publication
Journal or Publication Title: Hepatology
Volume: 7
Number: 2
Page Range: 362 - 366
DOI or Unique Handle: 10.1002/hep.1840070225
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0270-9139
Other ID: uls-drl:31735062129204, Starzl CV No. 767
Date Deposited: 08 Apr 2010 17:13
Last Modified: 14 Oct 2017 11:55
URI: http://d-scholarship.pitt.edu/id/eprint/4153

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