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In vitro immunosuppressive effects of FR 900506 on human T lymphocyte alloactivation

Zeevi, A and Duquesnoy, R and Eiras, G and Todo, S and Makowka, L and Starzl, T (1987) In vitro immunosuppressive effects of FR 900506 on human T lymphocyte alloactivation. Surgical Research Communications, 1 (4). 315 - 323. ISSN 0882-9233

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Abstract

FR 900506 (FR) is a new immunosuppressive drug which prolongs allograft survival. Our studies have compared the in vitro inhibitory effects of FR and cyclosporine (CsA) on human lymphocyte proliferation. Considerably lower doses of FR were required to induce inhibition of lymphocyte proliferation induced by concanavalin A (Con A) stimulation or in primary mixed lymphocyte reactions (MLR). Similar differences between FR and CsA were observed with the secondary stimulation of alloactivated T cells generated in MLR or propagated from liver transplant biopsies. These observations provide further evidence that FR is about 500 fold more potent than CsA and may be a useful immunosuppressive agent in organ transplantation.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Zeevi, A
Duquesnoy, R
Eiras, G
Todo, S
Makowka, L
Starzl, Ttes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1987
Date Type: Publication
Journal or Publication Title: Surgical Research Communications
Volume: 1
Number: 4
Page Range: 315 - 323
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0882-9233
Other ID: uls-drl:31735062129238, Starzl CV No. 770
Date Deposited: 08 Apr 2010 17:13
Last Modified: 04 Feb 2019 15:56
URI: http://d-scholarship.pitt.edu/id/eprint/4156

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