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Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine.

Murase, N and Todo, S and Lee, PH and Lai, HS and Chapman, F and Nalesnik, MA and Makowka, L and Starzl, TE (1987) Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine. Transplant Proc, 19 (5 Supp). 71 - 75. ISSN 0041-1345

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Abstract

In rats, FK significantly prolonged heterotopic heart graft survival over a wide dose range when given for 2 weeks starting on the day of the operation. Brief courses of FK for one to four days preoperatively, and especially beginning four days postoperatively, allowed long subsequent survival of heart grafts in otherwise untreated recipients. The seeming acceptance of the grafts with postoperative FK treatment was largely but not exclusively donor specific when tested eight days after the last FK dose by second grafts from the same donor v third-party donor grafts. FK in minimally therapeutic doses was synergistic with suboptimal doses of CyA.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Murase, N
Todo, S
Lee, PH
Lai, HS
Chapman, F
Nalesnik, MA
Makowka, L
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: October 1987
Date Type: Publication
Journal or Publication Title: Transplant Proc
Volume: 19
Number: 5 Supp
Page Range: 71 - 75
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Abdomen, Animals, Cyclosporins, Drug Evaluation, Preclinical, Drug Synergism, Drug Therapy, Combination, Graft Survival, Heart Transplantation, Immunosuppressive Agents, Male, Pyridines, Rats, Rats, Inbred Strains, Tacrolimus
ISSN: 0041-1345
Funders: NIDDK NIH HHS (R01 DK029961-19), NIADDK NIH HHS (AM-29961)
Other ID: uls-drl:31735062129246, Starzl CV No. 771
Date Deposited: 08 Apr 2010 17:13
Last Modified: 03 Dec 2022 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/4157

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