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Orthotopic liver transplantation in dogs receiving FK-506.

Todo, S and Podesta, L and ChapChap, P and Kahn, D and Pan, CE and Ueda, Y and Okuda, K and Imventarza, O and Casavilla, A and Demetris, AJ (1987) Orthotopic liver transplantation in dogs receiving FK-506. Transplant Proc, 19 (5 Supp). 64 - 67. ISSN 0041-1345

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Abstract

Ten dogs that survived the perioperative events of liver transplantation were treated with 1 mg/kg/d oral FK. Eight of the recipients lived for at least 1 month postoperatively, and seven are still alive with normal hepatic function after 35 to 65 days. The consistency and good quality of results with this difficult transplant preparation using FK, in spite of its rumored great toxicity in dogs, have highlighted the importance of further developing the drug.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Todo, S
Podesta, L
ChapChap, P
Kahn, D
Pan, CE
Ueda, Y
Okuda, K
Imventarza, O
Casavilla, A
Demetris, AJ
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: October 1987
Date Type: Publication
Journal or Publication Title: Transplant Proc
Volume: 19
Number: 5 Supp
Page Range: 64 - 67
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Animals, Body Weight, Dogs, Drug Evaluation, Preclinical, Graft Rejection, Immunosuppressive Agents, Liver Function Tests, Liver Transplantation, Pyridines, Tacrolimus
ISSN: 0041-1345
Funders: NIDDK NIH HHS (R01 DK029961-20), NIADDK NIH HHS (AM-29961)
Other ID: uls-drl:31735062129261, Starzl CV No. 773
Date Deposited: 08 Apr 2010 17:13
Last Modified: 14 Oct 2017 05:56
URI: http://d-scholarship.pitt.edu/id/eprint/4159

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