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Relationship between Pulmonary Airflow (FEV1) and Use of Menthol vs Non-menthol Cigarettes in the COPDGene® Population

Kanyuch, Jodi (2021) Relationship between Pulmonary Airflow (FEV1) and Use of Menthol vs Non-menthol Cigarettes in the COPDGene® Population. Master Essay, University of Pittsburgh.

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Chronic Obstructive Pulmonary disease (COPD) is the fourth leading causes of death in the United States and a major public health issue. The relationship between smoking and COPD is well known as smoking is the primary risk factor for development of COPD. However, whether smoking mentholated versus non-mentholated cigarettes is associated with an increased risk of developing COPD is unclear. For this project, I analyzed data on pulmonary function (as measured by forced expiratory volume, percent predicted FEV1, ppFEV1) on 2858 European Americans (EA) and 2790 African Americans (AA), a total of 5648 participants who had a smoking history greater than 10 pack years, from the COPDGene® multicenter observational study. Men comprised 55.1% of the population and 44.9% were women. EA participants were significantly older than AA participants (57.8 versus 53.5 years, respectively, p<0.00001), had smoked substantially more pack-years (47.6 versus 38.1 pack-years, respectively, p<0.00001), and had lower ppFEV1 (76.4% predicted versus 84.9% predicted, respectively, p< 0.0001). Overall, significantly more European Americans smoked non-menthol cigarettes than menthol cigarettes, 55.8% versus 44.3%, respectively (p-value < 0.00001), whereas significantly more African Americans smoked menthol cigarettes than non-menthol cigarettes, 88.2% versus 11.8%, respectively p-value ˂ 0.00001). An analysis of the effects of age, pack-years, race, and menthol cigarette smoking on (adjusted) ppFEV1 revealed that ppFEV1 significantly decreased with increasing age and pack-years, and also was significantly higher in AA versus EA participants (p<0.000001 for all). Menthol versus non-menthol cigarettes smoking was not associated with ppFEV1, when race was included, although interactions among the variables was not explored. These results confirm previous relationships regarding the effects of age, race, and pack-years on ppFEV1, but identified no independent effects of menthol versus non-menthol cigarette smoking. However, the relationship between ppFEV1 and age, pack-years, menthol cigarette smoking, race, and sex was not straightforward and additional analyses need to be done. My results indicate that the relationships between ppFEV1, age, pack-years and menthol cigarette smoking differ by sex and between races, thus, different public health interventions to facilitate smoking cessation and reduce COPD will need to be targeted to specific groups.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Kanyuch, Jodikanyuchja@gmail.comJOK164
ContributionContributors NameEmailPitt UsernameORCID
Thesis advisorKammerer, Candacecmk3@pitt.educmkUNSPECIFIED
Committee MemberSciurba, Franksciurbafc@upmc.eduUNSPECIFIEDUNSPECIFIED
Date: 31 August 2021
Date Type: Completion
Submission Date: 11 August 2021
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 41
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Public Health Genetics
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Uncontrolled Keywords: COPD FEV1
Date Deposited: 31 Aug 2021 20:25
Last Modified: 31 Aug 2021 20:25


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