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LONG TERM RESULTS OF HEPATIC TRANSPLANTATION DURING THE CYCLOSPORINE ERA: THE PITTSBURGH EXPERIENCE.

Esquivel, Carlos O and Marino, Ignazio R and Iwatsuki, Shunzaburo and Gordon, Robert D and Van Thiel, David and Starzl, Thomas E (1987) LONG TERM RESULTS OF HEPATIC TRANSPLANTATION DURING THE CYCLOSPORINE ERA: THE PITTSBURGH EXPERIENCE. Transplant Clin Immunol, 19. 185 - 196. ISSN 0168-7085

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Abstract

We have reviewed the long term results of the first 500 liver transplant recipients performed by our group during the cyclosporine era. Three hundred and forty-nine recipients lived (69.8%) more than 1 year and the projected 5 year actuarial survival for this sub-group of patients is 88%. The two most common causes of graft dysfunction after the first year were recurrence of the original disease, usually malignancy, and chronic rejection. Most episodes of rejection can be controlled with medical treatment; however, 16 patients of 34 patients who experienced rejection episodes after the first year required retransplantation. Eleven of these 16 are currently alive and free of jaundice. Another common cause of late graft dysfunction is biliary strictures. The recognized side effects of cyclosporine such as nephrotoxicity and lymphoproliferative disease have been lesser problems as a result of the judicious use of the drug. The quality of life of long term survivors is excellent.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Esquivel, Carlos O
Marino, Ignazio R
Iwatsuki, Shunzaburo
Gordon, Robert D
Van Thiel, David
Starzl, Thomas Etes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1987
Date Type: Publication
Journal or Publication Title: Transplant Clin Immunol
Volume: 19
Page Range: 185 - 196
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0168-7085
Funders: NIDDK NIH HHS (R01 DK029961-19)
Other ID: uls-drl:31735062129444, Starzl CV No. 792
Date Deposited: 08 Apr 2010 17:13
Last Modified: 05 Dec 2017 17:00
URI: http://d-scholarship.pitt.edu/id/eprint/4178

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