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Effect of partial portal vein ligation on hepatic regeneration

Kahn, D and Kajani, M and Zeng, Q and Lai, HS and Eagon, PK and Makowka, L and Starzl, TE and Van Thiel, DH (1988) Effect of partial portal vein ligation on hepatic regeneration. Journal of Investigative Surgery, 1 (4). 267 - 276. ISSN 0894-1939

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To evaluate the effect of portal hypertension and diminished portal venous blood flow to the liver on hepatic regeneration, male rats were subjected to partial portal vein ligation and subsequently to a two-thirds partial hepatectomy. The levels of ornithine decarboxylase activity at 6 h after partial hepatectomy were greater (p > 0.001) in the rats with prior partial portal vein ligation than in those without portal hypertension. The rats with prior partial portal vein ligation also had greater (p > 0.005) levels of thymidine kinase activity at 48 h after partial hepatectomy than did those without portal hypertension. Hepatic sex hormone receptor activity was not affected by prior partial portal vein ligation either before or after partial hepatectomy. The reductions in both estrogen and androgen receptor activity observed in the hepatic cytosol after partial hepatectomy were similar to those observed in control animals. These data indicate that animals with portal hypertension having a diminished hepatic portal blood flow have a normal capacity to regenerate hepatic mass following a hepatic resection © 1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Kahn, D
Kajani, M
Zeng, Q
Lai, HS
Eagon, PK
Makowka, L
Starzl, TEtes11@pitt.eduTES11
Van Thiel, DH
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1988
Date Type: Publication
Journal or Publication Title: Journal of Investigative Surgery
Volume: 1
Number: 4
Page Range: 267 - 276
DOI or Unique Handle: 10.3109/08941938809141092
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0894-1939
Other ID: uls-drl:31735062129691, Starzl CV No. 818
Date Deposited: 08 Apr 2010 17:14
Last Modified: 02 Feb 2019 13:55


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