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The Role of Molecular Testing for the Indeterminate Thyroid FNA

Rossi, Esther Diana and Pantanowitz, Liron and Faquin, William C. (2019) The Role of Molecular Testing for the Indeterminate Thyroid FNA. Genes, 10 (10). p. 736. ISSN 2073-4425

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Thyroid nodules are common in the adult population where a majority are benign and only 4.0% to 6.5% are malignant. Fine needle aspiration (FNA) is a key method used in the early stages to evaluate and triage patients with thyroid nodules. While a definitive cytological diagnosis is provided in more than 70–75% of all thyroid FNA cases, the group of indeterminate lesions offers a challenge in terms of interpretation and clinical management. Molecular testing platforms have been developed, are recognized as an option by the 2015 American Thyroid Association Guidelines, and are frequently used in conjunction with FNA as an integral part of the cytologic evaluation. In this review, the utility of molecular testing options for nodules assigned to the group of indeterminate thyroid FNAs is described.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Rossi, Esther Diana
Pantanowitz, Lironpantanowitzl@upmc.edu0000-0001-8182-5503
Faquin, William C.0000-0002-9043-7171
Date: 23 September 2019
Date Type: Publication
Journal or Publication Title: Genes
Volume: 10
Number: 10
Publisher: MDPI AG
Page Range: p. 736
DOI or Unique Handle: 10.3390/genes10100736
Schools and Programs: School of Medicine > Pathology
Refereed: Yes
Uncontrolled Keywords: fine needle aspiration, cytology, thyroid cancers, molecular testing, personalized medicine
ISSN: 2073-4425
Official URL:
Funders: Elizabeth and Michael Ruane Center for Endocrine Tumors Fund
Article Type: Review
Date Deposited: 05 Jan 2022 16:42
Last Modified: 05 Jan 2022 16:42


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