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Experience With Orthoclone OKT3 Monoclonal Antibody in Liver Transplantation

Gordon, RD and Tzakis, AG and Iwatsuki, S and Todo, S and Esquivel, CO and Marsh, JW and Stieber, A and Makowka, L and Starzl, TE (1988) Experience With Orthoclone OKT3 Monoclonal Antibody in Liver Transplantation. American Journal of Kidney Diseases, 11 (2). 141 - 144. ISSN 0272-6386

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Abstract

Experience with the use of Orthoclone OKT3 monoclonal antibody for the treatment of acute cellular rejection in a series of 130 human orthotopic liver transplantations is reviewed. Treatment was highly effective in reversing rejection, in reducing the rate of retransplantation, and in lowering patient mortality. OKT3 was also useful for cyclosporine sparing in patients with poor renal function, hypertension, or CNS toxicity. There was a significant incidence of opportunistic infection associated with the use of OKT3. © 1988, National Kidney Foundation. All rights reserved.. All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Gordon, RD
Tzakis, AG
Iwatsuki, S
Todo, S
Esquivel, CO
Marsh, JW
Stieber, A
Makowka, L
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1988
Date Type: Publication
Journal or Publication Title: American Journal of Kidney Diseases
Volume: 11
Number: 2
Page Range: 141 - 144
DOI or Unique Handle: 10.1016/s0272-6386(88)80199-9
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0272-6386
Other ID: uls-drl:31735062129915, Starzl CV No. 840
Date Deposited: 08 Apr 2010 17:14
Last Modified: 13 Oct 2017 21:55
URI: http://d-scholarship.pitt.edu/id/eprint/4226

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