Morenikeji, Olanrewaju
(2022)
Elucidating variable immune responses regulation through non-coding RNA-target interactomes.
In: Pitt Momentum Fund 2022.
Abstract
Non-coding RiboNucleic Acids (ncRNAs) are small molecules involved in modulation of gene expression. There is very scant information on how they are involved with our body’s response to infectious diseases. A better understanding of how our immune system is regulated through these ncRNAs in the presence of germs would significantly benefit disease surveillance and design of new drugs for diseases like COVID-19. There is major variation in host-pathogen relationships leading to balanced or unbalanced immune responses. Since these small molecules can bind multiple gene targets simultaneously to regulate their expression, they are also important as diagnostic markers. This project aims to manipulate ncRNA-targets to circumvent negative regulators of the immune system. Elucidating these small molecules in the context of immune response and associated cytokine storms in the case of coronaviruses is highly pertinent.
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