Wells, Alexandra Isabella
(2022)
The roles of the neonatal Fc receptor and interferons in echovirus pathogenesis.
Doctoral Dissertation, University of Pittsburgh.
(Unpublished)
Abstract
Enterovirus infections are major sources of disease in humans. Echoviruses are a major subtype of enteroviruses and are especially devastating to neonates and young children. Despite the number of infections and potential adverse outcomes, the basic determinants of pathogenesis for echoviruses is poorly understood. This dissertation describes the identification of the neonatal Fc receptor (FcRn) as the entry receptor for echoviruses and the subsequent development of new in vivo models that fully recapitulate echovirus disease as well as establish the role of interferons during echovirus infections. Collectively, these studies show (1) that human FcRn is the entry receptor for echoviruses, (2) that human FcRn and type I interferons mediate infection in the liver, (3) that type I and III interferons play differential roles in infection of the gastrointestinal tract and dissemination to other tissues, (4) the meninges of the brain are the main target of echovirus infection and (5) that the host interferon stimulated genes that target enteroviruses function in pan-enterovirus- and enterovirus-species specific manners.
Share
Citation/Export: |
|
Social Networking: |
|
Details
Item Type: |
University of Pittsburgh ETD
|
Status: |
Unpublished |
Creators/Authors: |
|
ETD Committee: |
|
Date: |
12 May 2022 |
Date Type: |
Publication |
Defense Date: |
28 February 2022 |
Approval Date: |
12 May 2022 |
Submission Date: |
25 March 2022 |
Access Restriction: |
1 year -- Restrict access to University of Pittsburgh for a period of 1 year. |
Number of Pages: |
247 |
Institution: |
University of Pittsburgh |
Schools and Programs: |
School of Medicine > Microbiology and Immunology |
Degree: |
PhD - Doctor of Philosophy |
Thesis Type: |
Doctoral Dissertation |
Refereed: |
Yes |
Uncontrolled Keywords: |
Echovirus, interferon |
Date Deposited: |
13 May 2022 02:59 |
Last Modified: |
12 May 2023 05:15 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/42411 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Actions (login required)
 |
View Item |