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Liver transplantation in the treatment of bleeding esophageal varices

Iwatsuki, S and Starzl, TE and Todo, S and Gordon, RD and Tzakis, AG and Marsh, JW and Makowka, L and Koneru, B and Stieber, A and Klintmalm, G and Husberg, B and Van Thiel, D (1988) Liver transplantation in the treatment of bleeding esophageal varices. Surgery, 104 (4). 697 - 705. ISSN 0039-6060

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From March 1980 to July 1987, 1000 patients with various end-stage liver diseases received orthotopic liver transplants. Of the 1000 patients, three hundred two had definite histories of bleeding from esophageal varices before transplantation. There were 287 patients with nonalcoholic liver diseases and 15 patients with alcoholic cirrhosis. All patients had very poor liver function, which was the main indication for liver transplantation. One- through 5-year actuarial survival rates of the 302 patients were 79%, 74%, 71%, and 71%, respectively. These survival rates are far better than those obtained with other available modes of treatment for bleeding varices when liver disease is advanced. Long-term sclerotherapy is the treatment of primary choice for bleeding varices. Patients in whom sclerotherapy fails should be considered for liver transplantation unless clear contraindications exist.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Iwatsuki, S
Starzl, TEtes11@pitt.eduTES11
Todo, S
Gordon, RD
Tzakis, AG
Marsh, JW
Makowka, L
Koneru, B
Stieber, A
Klintmalm, G
Husberg, B
Van Thiel, D
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1988
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 104
Number: 4
Page Range: 697 - 705
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062130111, Starzl CV No. 861
Date Deposited: 08 Apr 2010 17:14
Last Modified: 13 Oct 2017 21:55


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