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Orthotopic liver transplantation for alcoholic cirrhosis.

Starzl, TE and Van Thiel, D and Tzakis, AG and Iwatsuki, S and Todo, S and Marsh, JW and Koneru, B and Staschak, S and Stieber, A and Gordon, RD (1988) Orthotopic liver transplantation for alcoholic cirrhosis. JAMA, 260 (17). 2542 - 2544. ISSN 0098-7484

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Fifteen patients with Laennec's cirrhosis underwent orthotopic liver transplantation between 1963 and the end of 1979. The first eight patients died perioperatively or within two months, but four of the next seven patients had long survival; three are still alive after 11 to 14 years. After the introduction of cyclosporine therapy, 41 more patients with alcoholic cirrhosis were treated with liver transplantation from 1980 to June 1987. The one-year survival is 73.2%, and, after one to three years, 28 (68%) of the recipients are living. Of the 35 patients in the combined old and new series who lived for six months or longer, only two returned to alcohol abuse. Social and vocational rehabilitation has been the rule in these recipients who were selected primarily because of urgency of need, because they or their families insisted on treatment, and because they and their families thereby committed themselves to long-standing programs of alcoholism care.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Van Thiel, D
Tzakis, AG
Iwatsuki, S
Todo, S
Marsh, JW
Koneru, B
Staschak, S
Stieber, A
Gordon, RD
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 4 November 1988
Date Type: Publication
Journal or Publication Title: JAMA
Volume: 260
Number: 17
Page Range: 2542 - 2544
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Adult, Aged, Alcoholism, Cyclosporins, Ethics, Medical, Female, Follow-Up Studies, Humans, Liver Cirrhosis, Alcoholic, Liver Transplantation, Male, Middle Aged, Prognosis
ISSN: 0098-7484
Funders: NIDDK NIH HHS (R01 DK029961-19), NIADDK NIH HHS (AM 29961)
Other ID: uls-drl:31735062130285, Starzl CV No. 878
Date Deposited: 08 Apr 2010 17:15
Last Modified: 13 Oct 2017 21:55


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