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Infections with cytomegalovirus and other herpesviruses in 121 liver transplant recipients: Transmission by donated organ and the effect of OKT3 antibodies

Singh, N and Dummer, JS and Kusne, S and Breinig, MK and Armstrong, JA and Makowka, L and Starzl, TE and Ho, M (1988) Infections with cytomegalovirus and other herpesviruses in 121 liver transplant recipients: Transmission by donated organ and the effect of OKT3 antibodies. Journal of Infectious Diseases, 158 (1). 124 - 131. ISSN 0022-1899

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Abstract

One hundred twenty-one adult liver transplant recipients were studied for the incidence, risk factors, and morbidity associated with herpesviruses infections after transplantation. The overall incidence of infection was 59% for cytomegalovirus (CMV), 35% for herpes simplex virus (HSV), 25% for Epstein-Barr virus (EBV), and 7% for varicella-zoster virus (VZV). Primary CMV infection occurred in 46% and reactivation CMV infection in 67% of the susceptible recipients. Symptomatic and disseminated CMV diseases were more common when patients developed primary infection (P < .01, for both comparisons). The donor organ appeared to be the only important source of CMV infection in seronegative recipients. The use of OKT3 antibodies was associated with disseminated CMV disease in patients with primary infection (P = .04) but not with reactivation infection (P > .10). Although most HSV infections were oral or genital reactivations, three cases of HSV hepatitis occurred - one was primary infection. Symptomatic reactivations of HSV were observed in 53% of HSV-seropositive recipients who received OKT3, versus 31% of seropositive recipients who did not receive OKT3 (P = .05).


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Singh, N
Dummer, JS
Kusne, S
Breinig, MK
Armstrong, JA
Makowka, L
Starzl, TEtes11@pitt.eduTES11
Ho, Mmonto@pitt.eduMONTO
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1988
Date Type: Publication
Journal or Publication Title: Journal of Infectious Diseases
Volume: 158
Number: 1
Page Range: 124 - 131
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0022-1899
Other ID: uls-drl:31735062130301, Starzl CV No. 880
Date Deposited: 08 Apr 2010 17:15
Last Modified: 13 Oct 2017 20:57
URI: http://d-scholarship.pitt.edu/id/eprint/4266

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