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Histocompatibility and liver transplant outcome. Does HLA exert a dualistic effect?

Markus, BH and Duquesnoy, RJ and Gordon, RD and Fung, JJ and Vanek, M and Klintmalm, G and Bryan, C and Van Thiel, D and Starzl, TE (1988) Histocompatibility and liver transplant outcome. Does HLA exert a dualistic effect? Transplantation, 46 (3). 372 - 377. ISSN 0041-1337

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Abstract

An analysis of more than 500 liver transplants has demonstrated that HLA compatibility is associated with diminished allograft survival. Liver transplants with zero mismatches for class I and/or class II HLA antigens have shown significantly lower acturial survival rates than transplants with one or more mismatches for these loci. In a group of 199 failed liver allografts from patients undergoing retransplantation, a higher incidence of failure due to rejection correlated with a lower degree of HLA compatibility especially for HLA-DR. In contrast, the incidence of liver transplant failures due to primary nonfunction was relatively higher with HLA-DR compatible transplants. Considering the role of HLA as a restriction element in cellular interactions during the immune response, these findings suggest that HLA compatibility may have a dualistic effect on liver transplant outcome. On one hand, HLA compatibility reduced transplant rejection - and on the other hand, it may enhance other immunological mechanisms leading to allograft dysfunction, particularly in patients at risk of developing recurrent autoimmune diseases or infection.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Markus, BH
Duquesnoy, RJ
Gordon, RD
Fung, JJ
Vanek, M
Klintmalm, G
Bryan, C
Van Thiel, D
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 16 November 1988
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 46
Number: 3
Page Range: 372 - 377
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062130368, Starzl CV No. 886
Date Deposited: 08 Apr 2010 17:15
Last Modified: 13 Oct 2017 21:56
URI: http://d-scholarship.pitt.edu/id/eprint/4272

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