Pancreatitis following liver transplantation

Alexander, JA and Demetrius, AJ and Gavaler, JS and Makowka, L and Starzl, TE and Van Thiel, DH (1988) Pancreatitis following liver transplantation. Transplantation, 45 (6). 1062 - 1065. ISSN 0041-1337

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Abstract

Since 1981, when the liver transplantation program was initiated at the University of Pittsburgh, we have been impressed with the prevalence of pancreatitis occurring following liver transplantation in patients transplanted for hepatitis B—related liver disease. To either confirm this clinical impression or refute it, the records of the 27 HbsAg+ patients and those of an additional 24 HbsAg“but HbcAb and/or HbsAb+ patients who underwent orthotopic liver transplantation were reviewed to determine the prevalence of clinical pancreatitis and hyperamylasemia (biochemical pancreatitis) following liver transplantation (OLTx). Post-OLTx hyperamylasemia occurred significantly more frequently in HbsAg+ patients (6/27) than it did in the HbsAg- patients (0/24) (P<0.05). More importantly, clinical pancreatitis occurred in 14% (4/27) of the HbsAg+ patients and 0% (0/24) of the HbsAg- patients. Interestingly, in each case, the pancreatitis was associated with the occurrence of acute hepatitis B infection of the allograft. Based upon these data, we conclude that pancreatitis occurring after liver transplantation is more common in patients transplanted for active viral liver disease caused by hepatitis B than in those with inactive viral liver disease. These observations suggest that pancreatitis occurring in, at least some cases following liver transplantation for viral liver disease, may result from hepatitis B virus infection of the pancreas. © 1988 by The Williams and Wilkins Co.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Alexander, JA Demetrius, AJ Gavaler, JS Makowka, L Starzl, TE tes11@pitt.edu TES11 Van Thiel, DH
Centers:	Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date:	1 January 1988
Date Type:	Publication
Journal or Publication Title:	Transplantation
Volume:	45
Number:	6
Page Range:	1062 - 1065
DOI or Unique Handle:	10.1097/00007890-198806000-00012
Institution:	University of Pittsburgh
Refereed:	Yes
ISSN:	0041-1337
Other ID:	uls-drl:31735062130426, Starzl CV No. 892
Date Deposited:	08 Apr 2010 17:15
Last Modified:	22 Jun 2021 13:56
URI:	http://d-scholarship.pitt.edu/id/eprint/4278

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