Stackhouse, Laura N
(2022)
CREBRF Missense Variant rs373863828 and Relative Grip Strength.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Grip strength has been associated with many conditions and can act not only as an indicator of general fitness and muscle strength, but also as a predictor of cognitive decline, diabetes, and more. We previously found that a missense variant, rs373863828, in the CREBRF gene was associated with increased fat storage in cell models, and with higher body mass index and decreased risk of diabetes in humans. This Soifua Manuia Study of 519 adults from Samoa explores how grip strength is distributed and what factors are correlated with grip strength, and also looks into the association between rs373863828 and grip strength in the Samoan population.
From the analysis, the data showed several patterns of note including that relative grip strength appears to stay constant as a function of age in biological females, but relative grip strength shows age-related decline in biological males, and that mean relative grip strength decreases as the number of minor A alleles increases (p=4.471e-04). Given the interesting association between the minor A allele and relative grip strength, more research into the underlying mechanisms of relative grip strength and into the functions of this missense mutation is needed. This study provides more information about grip strength in this understudied population so that future work may specify cut-off points for measuring sarcopenia and frailty in order to improve clinical practice and patient care.
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Details
Item Type: |
University of Pittsburgh ETD
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Status: |
Unpublished |
Creators/Authors: |
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ETD Committee: |
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Date: |
12 May 2022 |
Date Type: |
Publication |
Defense Date: |
13 April 2022 |
Approval Date: |
12 May 2022 |
Submission Date: |
27 April 2022 |
Access Restriction: |
2 year -- Restrict access to University of Pittsburgh for a period of 2 years. |
Number of Pages: |
75 |
Institution: |
University of Pittsburgh |
Schools and Programs: |
School of Public Health > Human Genetics |
Degree: |
MS - Master of Science |
Thesis Type: |
Master's Thesis |
Refereed: |
Yes |
Uncontrolled Keywords: |
Genetic, Human Genetics, CREBRF, Samoans, Grip Strength, Relative Grip Strength, rs373863828 |
Date Deposited: |
12 May 2022 14:32 |
Last Modified: |
16 Jun 2022 15:11 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/42788 |
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