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CREBRF Missense Variant rs373863828 and Relative Grip Strength

Stackhouse, Laura N (2022) CREBRF Missense Variant rs373863828 and Relative Grip Strength. Master's Thesis, University of Pittsburgh. (Unpublished)

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Grip strength has been associated with many conditions and can act not only as an indicator of general fitness and muscle strength, but also as a predictor of cognitive decline, diabetes, and more. We previously found that a missense variant, rs373863828, in the CREBRF gene was associated with increased fat storage in cell models, and with higher body mass index and decreased risk of diabetes in humans. This Soifua Manuia Study of 519 adults from Samoa explores how grip strength is distributed and what factors are correlated with grip strength, and also looks into the association between rs373863828 and grip strength in the Samoan population.
From the analysis, the data showed several patterns of note including that relative grip strength appears to stay constant as a function of age in biological females, but relative grip strength shows age-related decline in biological males, and that mean relative grip strength decreases as the number of minor A alleles increases (p=4.471e-04). Given the interesting association between the minor A allele and relative grip strength, more research into the underlying mechanisms of relative grip strength and into the functions of this missense mutation is needed. This study provides more information about grip strength in this understudied population so that future work may specify cut-off points for measuring sarcopenia and frailty in order to improve clinical practice and patient care.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Stackhouse, Laura Nlns51@pitt.eduLNS510000-0003-4078-1561
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairWeeks, Daniel Eweeks@pitt.eduweeks0000-0001-9410-7228
Committee MemberShaffer, John Rjohn.r.shaffer@pitt.edujohn.r.shaffer
Committee MemberCarlson, Jenna Cjnc35@pitt.edujnc350000-0001-5483-0833
Date: 12 May 2022
Date Type: Publication
Defense Date: 13 April 2022
Approval Date: 12 May 2022
Submission Date: 27 April 2022
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 75
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Human Genetics
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Genetic, Human Genetics, CREBRF, Samoans, Grip Strength, Relative Grip Strength, rs373863828
Date Deposited: 12 May 2022 14:32
Last Modified: 16 Jun 2022 15:11


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