Hollnagel, Kaylee
(2022)
Chronic Inflammation and Glycemic Control: An Analysis of Type 2 Diabetes and Inflammatory Biomarkers in The Long Life Family Study.
Master Essay, University of Pittsburgh.
Abstract
Type 2 Diabetes (T2D) is associated with chronic low-level inflammation, presenting as elevated levels of biomarkers such as C-reactive protein (CRP), interleukin-6 (IL-6), and white blood cells. These biomarkers increase with age as well as diabetes onset and severity. Currently, little is known about inflammation and T2D among healthy agers. In this analysis, relationships between diabetes and prediabetes status, and CRP, IL-6, adiponectin, and neutrophil-to-lymphocyte ratio (NLR) were examined in the offspring of exceptionally long-lived individuals.
The Long Life Family Study is a multi-center prospective cohort study of exceptional longevity in two generation families. Of the 4,952 enrolled at Visit 1 (2006-2009), 3,229 individuals from the offspring generation were included in the current analyses. T2D was defined as FPG 126 mg/dL, HbA1c 6.5%, self-reported doctor’s diagnosis, or use of anti-diabetic medications. Prediabetes was defined as HbA1c 5.7 – 6.49%, FPG 100 mg/dL – 125.99 mg/dL, or non-fasting glucose 140 mg/dL – 199.99 mg/dL. Summary statistics of relevant variables stratified by family and diabetes status were assessed. Associations of glucose, HbA1c, and HOMA-IR with the inflammatory biomarkers were tested using partial correlations. Logistic regression analyses were used to assess inflammatory biomarkers as predictors of incident diabetes and prediabetes. Partial correlations and regressions were adjusted for age, BMI, sex, field center, lifestyle, and/or medications.
There were 83 and 352 incident T2D and prediabetes cases by Visit 2 (2014-2017). Baseline CRP, IL-6, and NLR were higher, and baseline adiponectin was lower in those with diabetes and prediabetes compared to nondiabetics (p<0.002). This was similarly seen among the spouses, except NLR (p<0.005). Positive correlations were seen between the glycemic control biomarkers and NLR, CRP, and IL-6, and negative correlations for adiponectin, all p<0.0001 except NLR. Most associations were attenuated after covariate adjustment, however, most correlations with adiponectin became stronger after adjusting for age and sex. Logistic regression analyses showed that adiponectin was significant in predicting diabetes and prediabetes incidence (p<0.0001), while NLR, CRP, and IL-6 were not.
While some differences in the inflammatory profiles of diabetic, prediabetic, and non-diabetic individuals may be present in exceptionally long-lived families, these relationships are complex and require further longitudinal analysis.
Share
Citation/Export: |
|
Social Networking: |
|
Details
Item Type: |
Other Thesis, Dissertation, or Long Paper
(Master Essay)
|
Status: |
Unpublished |
Creators/Authors: |
|
Contributors: |
Contribution | Contributors Name | Email | Pitt Username | ORCID  |
---|
Committee Chair | Zmuda, Joseph M. | zmudaj@edc.pitt.edu | zmudaj | UNSPECIFIED | Committee Member | Youk, Ada O. | ayouk@pitt.edu | ayouk | UNSPECIFIED | Committee Member | Miljkovic, Iva | miljkovici@edu.pitt.edu | miljkovici | UNSPECIFIED |
|
Date: |
17 May 2022 |
Date Type: |
Completion |
Submission Date: |
28 April 2022 |
Access Restriction: |
2 year -- Restrict access to University of Pittsburgh for a period of 2 years. |
Number of Pages: |
60 |
Institution: |
University of Pittsburgh |
Schools and Programs: |
School of Public Health > Epidemiology |
Degree: |
MPH - Master of Public Health |
Thesis Type: |
Master Essay |
Refereed: |
Yes |
Uncontrolled Keywords: |
Inflammatory Biomarkers, Neutrophil-to-Lymphocyte Ratio, Adiponectin, C-Reactive Protein, Interleukin-6, Aging, Diabetes Mellitus, Prediabetes |
Date Deposited: |
17 May 2022 15:58 |
Last Modified: |
17 May 2022 15:58 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/42826 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Actions (login required)
 |
View Item |