Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Effect of an antiandrogenic H<inf>2</inf> receptor antagonist on hepatic regeneration in rats

Kahn, D and Svanas, GW and Eagon, PK and Makowka, L and Podesta, L and Chapchap, P and Starzl, TE and Van Thiel, DH (1988) Effect of an antiandrogenic H<inf>2</inf> receptor antagonist on hepatic regeneration in rats. Journal of Laboratory and Clinical Medicine, 112 (2). 232 - 239. ISSN 0022-2143

[img]
Preview
PDF
Accepted Version
Available under License : See the attached license file.

Download (1MB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

Because biochemical 'feminization' of the liver in males is observed with hepatic regeneration and because the hepatic regenerative response in females is greater than that in males, the posibility that antiandrogens might potentiate liver regeneration was investigated. Before 70% hepatectomy, adult male Wistar rats were treated with cimetidine, and antiandrogenic H 2 antagonist, at doses up to 10 times greater than those used clinically. Control animals received either the saline vehicle or ranitidine, an H 2 antagonist without antiandrogenic properties. Treatment with cimetidine reduced the hepatic cytosolic androgen receptor content compared with ranitidine treatment. Hepatectomy caused a further reduction in androgen receptor activity in all groups. Hepatic cytosolic estrogen receptor activity was comparable in all groups throughout the study. Moreover, the rate of liver growth and the levels of ornithine decarboxylase and thymidine kinase activity induced as part of the regenerative response were similar in all groups. Thus, cimetidine, despite its ability to bind to androgen receptors, and ranitidine, an H 2 receptor antagonist without antiandrogen action, do not modulate the hepatic regenerative response to a 70% partial hepatectomy.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kahn, D
Svanas, GW
Eagon, PK
Makowka, L
Podesta, L
Chapchap, P
Starzl, TEtes11@pitt.eduTES11
Van Thiel, DH
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1988
Date Type: Publication
Journal or Publication Title: Journal of Laboratory and Clinical Medicine
Volume: 112
Number: 2
Page Range: 232 - 239
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0022-2143
Other ID: uls-drl:31735062130509, Starzl CV No. 900
Date Deposited: 08 Apr 2010 17:15
Last Modified: 13 Oct 2017 21:59
URI: http://d-scholarship.pitt.edu/id/eprint/4286

Metrics

Monthly Views for the past 3 years

Plum Analytics


Actions (login required)

View Item View Item