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Relationship Between Paternal Characteristics and Spontaneous Abortion

Doreswamy, Kruthika (2022) Relationship Between Paternal Characteristics and Spontaneous Abortion. Master Essay, University of Pittsburgh.

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Spontaneous abortion (SAB) is a pregnancy loss that occurs within the first 20 weeks of gestation. Most research has explored and demonstrated maternal influence on fetal development. However, emerging data suggests paternal characteristics could also influence pregnancy outcomes, including SAB. Previous studies report associations between paternal age, race, education, and SAB, although results are inconsistent. This study examined paternal characteristics associated with a medically reported SAB in a sample of married couples residing in rural to peri-urban India.

Women (n=1227) aged 15 to 35 years and their husbands were recruited before pregnancy or in their first trimester into the prospective Longitudinal Indian Family hEalth (LIFE) cohort study. We conducted cross-sectional analyses restricted to women who achieved a singleton pregnancy or a SAB and had a husband participating in the study (n=372). Paternal demographic, medical history, lifestyle factors and maternal pregnancy history variables were obtained from questionnaires administered at study enrollment. Initial exploratory analyses were conducted to examine the relationships between current alcohol consumption, current smoking, education, age, and a medically reported SAB. Crude odds ratio (ORs) and 95% confidence intervals (CIs) are reported.

This sample included 372 fathers ranging from 21 to 40 years (average 27 years). We examined the associations between current alcohol consumption (OR=0.91, 95% CI 0.50-1.72), current smoking (OR=0.57, 95% CI 0.21-1.35), higher education (OR=1.04, 95% CI 0.41-2.35), greater paternal age (>= 30 years; OR=1.31, 95% CI 0.67-2.50) and a SAB.

We did not identify any significant crude associations between paternal lifestyle factors and a SAB. We identified a non-significant trend of a 1.31 times increased risk of SAB in fathers with greater paternal age. Studies examining the influence of both paternal and maternal medical history, behavioral and demographic characteristics, and health on a range of prospectively measured pregnancy outcomes in diverse cohorts are needed.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Doreswamy, Kruthikakrd59@pitt.edukrd59
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairHill, Ashley V.avh16@pitt.eduavh16UNSPECIFIED
Committee MemberKohan, Alison B.akohan@pitt.eduakohanUNSPECIFIED
Committee MemberHaggerty, Catherine L.haggertyc@edc.pitt.eduhaggertycUNSPECIFIED
Date: 17 May 2022
Date Type: Completion
Submission Date: 29 April 2022
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 48
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Uncontrolled Keywords: birth outcomes, reproductive health
Date Deposited: 17 May 2022 13:48
Last Modified: 17 May 2022 13:48


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