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Humoral and Cell Mediated Immune Dynamics of SARS-CoV-2

Cuff, Deirdre E (2022) Humoral and Cell Mediated Immune Dynamics of SARS-CoV-2. Master Essay, University of Pittsburgh.

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Background: The ongoing Covid-19 pandemic has been characterized by waves of new cases, vaccinations, and variants. Understanding the impact of these cumulative exposures on immunity to circulating SARS-CoV-2 is needed to improve public health recommendations. Global vaccination efforts must utilize newly available information about SARS-CoV-2 correlates of immunity to improve efficacy and efficiency.
Objective: This essay aims to describe what is known and unknown about the adaptive immune response to SARS-CoV-2 infection and vaccination.
Review: I analyzed the dynamics of antibody, B cell, and T cell responses to various Covid-19 exposures and characterized their role as correlates of immune protection against SARS-CoV-2 infection. I describe potential flaws in our assessment of vaccine efficacy and propose areas of interest for future research
Conclusion: T cell responses to SARS-CoV-2 better describe the effector functions of the host immune response than antibody titers. Vaccines effectively prevent against symptomatic and severe Covid-19 disease. Future research is needed to accurately describe how antibody, B cell, and T cell responses serve as a correlate of immunity
Public Health Significance: The dynamics described in this paper suggest that the basis of current vaccine recommendations may be improved. Elucidating these characteristics of immunity will inform vaccination efforts and improve strategies to control the spread of Covid-19.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Cuff, Deirdre Edec97@pitt.edudec970000-0001-8091-7262
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairMailliard, Robbierbm19@pitt.edurbm19UNSPECIFIED
Committee MemberSluis-Cremer, Nicnps2@pitt.edunps2UNSPECIFIED
Date: 17 May 2022
Date Type: Completion
Submission Date: 29 April 2022
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 29
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Infectious Diseases and Microbiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Uncontrolled Keywords: Covid-19, adaptive immunity
Date Deposited: 17 May 2022 13:27
Last Modified: 17 May 2022 13:27


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