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Principal Component Analysis observing different parameters of medical factors influencing dental health conditions of pediatric patients

Ulery, Gabrielle (2022) Principal Component Analysis observing different parameters of medical factors influencing dental health conditions of pediatric patients. Master's Thesis, University of Pittsburgh. (Unpublished)

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Pediatric patients are in comparison extremely different than adult patients. They require different types of care and more preventative oral health procedures. While this is true, it is important to understand variables and factors that could correlate with their dental health conditions and treatments. In this research experiment, we determined different parameters from pediatric patients medical and dental health evaluations to see if there is any similarity in specific medical factors influencing dental health conditions. Data from 528 pediatric subjects 0-18 of age were obtained from the Dental Registry and DNA Repository project. Data included demographics, self-reported medical history, medications taken, and oral health conditions. Principal component analysis (PCA) was used to cluster similar individuals aiming to generate homogeneous groups for future genetic studies. We found that patients were more similar in comparison than initially predicted. However, there was a trend suggesting there were two groups. These groups were further investigated by using single nucleotide polymorphisms marking TRAV4 and MMP2. There were no differences in the distribution of the SNP markers between the two groups. We cannot further explain why the two groups may differ, and future studies will aim to explain the PCA initial findings.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Ulery, Gabriellegau8@pitt.edugau8
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairVieira, Alexandre Rarv11@pitt.eduarv11
Committee MemberTaboas, Juanjmt106@pitt.edujmt106
Committee MemberModesto Vieira, Adrianaams208@pitt.eduams208
Date: 16 May 2022
Date Type: Publication
Defense Date: 13 April 2022
Approval Date: 16 May 2022
Submission Date: 2 May 2022
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 61
Institution: University of Pittsburgh
Schools and Programs: School of Dental Medicine > Dental Science
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: N/A
Date Deposited: 16 May 2022 12:49
Last Modified: 16 May 2022 12:49


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