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PARTICIPATION OF DENDRITIC CELLS IN VASCULAR LESIONS OF CHRONIC REJECTION OF HUMAN ALLOGRAFTS

Oguma, S and Zerbe, T and Banner, B and Starzl, T and Demetris, AJ (1988) PARTICIPATION OF DENDRITIC CELLS IN VASCULAR LESIONS OF CHRONIC REJECTION OF HUMAN ALLOGRAFTS. The Lancet, 332 (8617). 933 - 936. ISSN 0140-6736

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Abstract

Immunohistochemical techniques were used to investigate the pathogenesis of obliterative arteriopathy, a major obstacle to long-term solid organ allograft survival. T-lymphocytes, macrophages, and proliferating smooth muscle cells made up most of the thickened intima. More importantly, S100-protein-positive dendritic cells were also present in the intima, especially during active inflammation and smooth muscle cell proliferation. These are phenotypic characteristics of tissue "dendritic" cells, pivotal accessory cells in T-dependent immune reactions. Their localisation in the arterial wall signals the presence of an ongoing immunological reaction directed at native constituents of the artery or at exogenous antigens which permeate the damaged vessel wall. © 1988.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Oguma, S
Zerbe, T
Banner, B
Starzl, Ttes11@pitt.eduTES11
Demetris, AJ
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 22 October 1988
Date Type: Publication
Journal or Publication Title: The Lancet
Volume: 332
Number: 8617
Page Range: 933 - 936
DOI or Unique Handle: 10.1016/s0140-6736(88)92600-1
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0140-6736
Other ID: uls-drl:31735062130574, Starzl CV No. 907
PubMed ID: 2902383
Date Deposited: 08 Apr 2010 17:15
Last Modified: 27 Jan 2019 02:55
URI: http://d-scholarship.pitt.edu/id/eprint/4293

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