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Treatment of hepatic epithelioid hemangioendothelioma with liver transplantation

Marino, IR and Todo, S and Tzakis, MG and Klintmalm, G and Kelleher, M and Iwatsuki, S and Starzl, TE and Esquivel, CO (1988) Treatment of hepatic epithelioid hemangioendothelioma with liver transplantation. Cancer, 62 (10). 2079 - 2084. ISSN 0008-543X

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Ten patients received liver transplants for unresectable epithelioid hemangioendothelioma (EHE). At the time of transplantation, four patients had microscopic metastases to the hilar lymph nodes, and one of the four also had metastases to a rib. The fifth patient had metastases to the lung, pleura, and diaphragm. The remaining five patients were believed to be free of metastatic disease. Two of these five patients died of metastatic disease at 3 and 16 months, respectively, after transplantation. Interestingly, all five patients with metastatic involvement are currently alive 40.6 ± 22 months (mean ± standard error of mean [SEM]) after transplantation, although one of these patients currently has metastatic disease to the lungs and mediastinum. Thus, the projected 5‐year actuarial survival rate is 76%, with two patients at risk after the third year. In conclusion, liver transplantation is a reasonable procedure for bulky, otherwise unresectable, EHE even in the presence of metastatic disease. Copyright © 1988 American Cancer Society


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Marino, IR
Todo, S
Tzakis, MG
Klintmalm, G
Kelleher, M
Iwatsuki, S
Starzl, TEtes11@pitt.eduTES11
Esquivel, CO
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1988
Date Type: Publication
Journal or Publication Title: Cancer
Volume: 62
Number: 10
Page Range: 2079 - 2084
DOI or Unique Handle: 10.1002/1097-0142(19881115)62:10<2079::aid-cncr2820621002>;2-j
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0008-543X
Other ID: uls-drl:31735062130582, Starzl CV No. 908
Date Deposited: 08 Apr 2010 17:15
Last Modified: 01 Sep 2018 11:55


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