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Reciprocal Regulation between Primary Cilia and mTORC1

Lai, Yandong and Jiang, Y (2020) Reciprocal Regulation between Primary Cilia and mTORC1. Genes, 11 (6). p. 711. ISSN 2073-4425

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In quiescent cells, primary cilia function as a mechanosensor that converts mechanic signals into chemical activities. This unique organelle plays a critical role in restricting mechanistic target of rapamycin complex 1 (mTORC1) signaling, which is essential for quiescent cells to maintain their quiescence. Multiple mechanisms have been identified that mediate the inhibitory effect of primary cilia on mTORC1 signaling. These mechanisms depend on several tumor suppressor proteins localized within the ciliary compartment, including liver kinase B1 (LKB1), AMP-activated protein kinase (AMPK), polycystin-1, and polycystin-2. Conversely, changes in mTORC1 activity are able to affect ciliogenesis and stability indirectly through autophagy. In this review, we summarize recent advances in our understanding of the reciprocal regulation of mTORC1 and primary cilia.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Jiang, Yyuj5@pitt.eduYUJ5
Date: 26 June 2020
Date Type: Publication
Journal or Publication Title: Genes
Volume: 11
Number: 6
Publisher: MDPI AG
Page Range: p. 711
DOI or Unique Handle: 10.3390/genes11060711
Schools and Programs: School of Medicine > Pharmacology and Chemical Biology
Refereed: Yes
Uncontrolled Keywords: primary cilia, mTOR, mTORC1, autophagy, ciliogenesis, Tsc2
ISSN: 2073-4425
Official URL:
Funders: National Institutes of Health
Article Type: Review
Date Deposited: 12 May 2022 18:48
Last Modified: 12 May 2022 18:48


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