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Differences in Placental Imprinted Gene Expression across Preeclamptic and Non-Preeclamptic Pregnancies

Deyssenroth, Maya A. and Li, Qian and Escudero, Carlos and Myatt, Leslie and Chen, Jia and Roberts, James M. (2020) Differences in Placental Imprinted Gene Expression across Preeclamptic and Non-Preeclamptic Pregnancies. Genes, 11 (10). p. 1146. ISSN 2073-4425

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Preeclampsia is a multi-systemic syndrome that presents in approximately 5% of pregnancies worldwide and is associated with a range of subsequent postpartum and postnatal outcomes, including fetal growth restriction. As the placenta plays a critical role in the development of preeclampsia, surveying genomic features of the placenta, including expression of imprinted genes, may reveal molecular markers that can further refine subtypes to aid targeted disease management. In this study, we conducted a comprehensive survey of placental imprinted gene expression across early and late onset preeclampsia cases and preterm and term normotensive controls. Placentas were collected at delivery from women recruited at the Magee-Womens Hospital prenatal clinics, and expression levels were profiled across 109 imprinted genes. We observed downregulation of placental Mesoderm-specific transcript (MEST) and Necdin (NDN) gene expression levels (false discovery rate (FDR) < 0.05) among early onset preeclampsia cases compared to preterm controls. No differences in placental imprinted gene expression were observed between late onset preeclampsia cases and term controls. While few studies have linked NDN to pregnancy complications, reductions in MEST expression levels, as observed in our study, are consistently reported in the literature in relation to various pregnancy complications, including fetal growth restriction, suggesting a potential role for placental MEST expression as a biosensor of an adverse in utero environment.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Deyssenroth, Maya A.
Li, Qian
Escudero, Carlos
Myatt, Leslie
Chen, Jia
Roberts, James
Centers: Other Centers, Institutes, Offices, or Units > Magee-Women's Research Institute
Date: 29 September 2020
Date Type: Publication
Journal or Publication Title: Genes
Volume: 11
Number: 10
Publisher: MDPI AG
Page Range: p. 1146
DOI or Unique Handle: 10.3390/genes11101146
Schools and Programs: School of Medicine > Obstetrics, Gynecology, and Reproductive Sciences
Refereed: Yes
Uncontrolled Keywords: preeclampsia, placenta, imprinted genes
ISSN: 2073-4425
Official URL:
Funders: National Institutes of Health, National Institute of Environmental Health Sciences, National Institute on Alcohol Abuse and Alcoholism
Article Type: Research Article
Date Deposited: 12 May 2022 20:10
Last Modified: 12 May 2022 20:10


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