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Systematic Review and Meta-Analysis of Incidence and Prevalence of Endometriosis

Sarria-Santamera, Antonio and Orazumbekova, Binur and Terzic, Milan and Issanov, Alpamys and Chaowen, Chen and Asúnsolo-del-Barco, Angel (2020) Systematic Review and Meta-Analysis of Incidence and Prevalence of Endometriosis. Healthcare, 9 (1). p. 29. ISSN 2227-9032

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There is still much controversy regarding the epidemiology of endometriosis. The objective of this work is to conduct a systematic review, and if possible, proceed with a meta-analysis of studies that have analyzed the incidence and prevalence of this condition among women in the general population. The inclusion criteria were papers published after 1997 that had reported data of the incidence or prevalence of endometriosis. The PubMed search engine was used to identify papers meeting the inclusion criteria from 1997 to 2019, with an additional manual search for the identification of potentially eligible studies. The search was limited to papers published in English. The risk of bias was assessed according to the Joanna Briggs Institute Critical Appraisal Checklist. As a result, 27 papers, which included a total of 28,660,652 women, were classified according to the type of design and sources of information in five subgroups. Pooled estimates of prevalence for studies with self-reported data were 0.05 (95% CI: 0.03; 0.06), 0.01 for population-based integrated information systems (95% CI: 0.01; 0.02), and 0.04 (95% CI 0.04; 0.05) in studies using other designs. The pooled incidence rate of endometriosis was: 1.36 per 1000 person-years (PY) (95% CI: 1.09; 1.63) for studies based on hospital discharges, 3.53 per 1000 PY (95% CI: 2.06; 4.99) for cohort studies, and 1.89 per 1000 PY (95% CI: 1.42; 2.37) for population-based integrated information systems. Meta-analysis indicated high heterogeneity based on I-squared statistics. This significant variability may not only be due to methodological issues and the specific limitations of the different designs and data analyzed, including case definitions and subject selection strategies, but also to the inherent heterogeneity of endometriosis. Epidemiological studies with appropriate study designs remain necessary to provide a valid estimation of the population burden of endometriosis.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Sarria-Santamera, Antonio0000-0001-5734-7468
Orazumbekova, Binur
Terzic, Milanterzicmm@pitt.edu0000-0003-3914-5154
Issanov, Alpamys
Chaowen, Chen
Asúnsolo-del-Barco, Angel0000-0001-7898-4685
Date: 30 December 2020
Date Type: Publication
Journal or Publication Title: Healthcare
Volume: 9
Number: 1
Publisher: MDPI AG
Page Range: p. 29
DOI or Unique Handle: 10.3390/healthcare9010029
Schools and Programs: School of Medicine > Obstetrics, Gynecology, and Reproductive Sciences
Refereed: Yes
Uncontrolled Keywords: endometriosis, epidemiology, statistics, numerical data
ISSN: 2227-9032
Official URL:
Article Type: Review
Date Deposited: 18 May 2022 16:40
Last Modified: 18 May 2022 16:40


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