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Origin of lymph node-derived lymphocytes in human hepatic allografts

Fung, JJ and Zeevi, A and Demetris, AJ and Starzl, TE and Markus, B and Chen, K and Marrarri, M and Duquesnoy, RJ (1989) Origin of lymph node-derived lymphocytes in human hepatic allografts. Clinical Transplantation, 3 (6). 316 - 324. ISSN 0902-0063

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Hepatic allograft-derived lymph nodes were examined in the post-transplant period on order to determine the origin of lymphocytes and structural elements of the lymph node. Histologic assessment and immunohistochemical studies verified that T-cell infiltration of donor lymph nodes by recipient-derived lymphocytes occurred early in the post-transplant period. These T cells bore T-cell activation markers, e.g. TAC receptor and HLA-DR antigens. In addition, functional analysis demonstrated alloreactive T cells in secondary proliferation assays. The pattern of alloreactivity in these assays was dependent upon the phenotypic make-up (and therefore origin) of the lymphocytes within the lymph node. A gradual shift in predominance of donor-derived lymphocytes to recipient-derived lymphocytes occurred, but even late in the post-transplant course the stromal elements and a residium of lymphocytes within the lymph nodes continued to bear donor HLA antigens. The possible role of these 'passenger' lymphocytes in allograft immunity is discussed.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Fung, JJ
Zeevi, A
Demetris, AJ
Starzl, TEtes11@pitt.eduTES11
Markus, B
Chen, K
Marrarri, M
Duquesnoy, RJ
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Clinical Transplantation
Volume: 3
Number: 6
Page Range: 316 - 324
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0902-0063
Other ID: uls-drl:31735062130707, Starzl CV No. 920
Date Deposited: 08 Apr 2010 17:15
Last Modified: 03 Feb 2019 04:55


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