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[Long-term results of orthotopic liver transplantation during the cyclosporin era. 393 orthotopic liver transplantations accomplished in 313 consecutive patients at the Pittsburgh Transplantation Center].

Lerut, J and Stieber, AC and Makowka, L and Esquivel, CO and Iwatsuki, S and Gordon, RD and Starzl, TE (1989) [Long-term results of orthotopic liver transplantation during the cyclosporin era. 393 orthotopic liver transplantations accomplished in 313 consecutive patients at the Pittsburgh Transplantation Center]. Helv Chir Acta, 56 (3). 405 - 420. ISSN 0018-0181

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Abstract

During the cyclosporine era 1980-1984, 393 consecutive orthotopic liver transplantations (OLT) were performed in 313 patients at the University of Pittsburgh. This paper analyses the long-term results in this group of patients who have been followed-up for a minimum of three years. The results of OLT for different indications are discussed. The five-year survival rates after OLT for metabolic diseases, biliary atresia, primary biliary cirrhosis, posthepatic cirrhosis and primary hepatobiliary cancer are 75%, 68%, 60%, 58.9%, 53.2% and 23.8%, respectively. Recurrence of the primary disease after OLT is rare for benign diseases but rather frequent for malignant ones. The incidence of retransplantation for delayed rejection and for extrahepatic complications is discussed. The quality of life for most of the long-term survivors is good. Because of its good long-term results, OLT should become the therapy of choice in a lot of acute and chronic hepatopathies.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Lerut, J
Stieber, AC
Makowka, L
Esquivel, CO
Iwatsuki, S
Gordon, RD
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: August 1989
Date Type: Publication
Journal or Publication Title: Helv Chir Acta
Volume: 56
Number: 3
Page Range: 405 - 420
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Cyclosporins, Follow-Up Studies, Graft Rejection, Humans, Liver Diseases, Liver Transplantation, Middle Aged, Pennsylvania, Postoperative Complications, Survival Rate
ISSN: 0018-0181
Funders: NIDDK NIH HHS (R01 DK029961-19)
Other ID: uls-drl:31735062130749, Starzl CV No. 923
Date Deposited: 08 Apr 2010 17:15
Last Modified: 05 Dec 2017 16:59
URI: http://d-scholarship.pitt.edu/id/eprint/4309

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