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Radiofrequency Coil Design Methodology and Fast Imaging Analysis for Ultra-High Field Human MRI

Martins, Tiago Amaro (2022) Radiofrequency Coil Design Methodology and Fast Imaging Analysis for Ultra-High Field Human MRI. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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From the different human imaging modalities, the Magnetic Resonance Imaging (MRI) is
a non-invasive technique capable of high contrast imaging of soft tissues without use of ionizing
radiation. The upcoming ultra-high field (UHF) modality of MRI is getting increasingly more
development efforts specially after the Food and Drug Administration (FDA) clear 7 Tesla
scanners for clinical use. This drive towards higher field strengths allows research studies to take
advantage of the higher signal-to-noise ratio (SNR), higher blood-oxygen-level dependent
(BOLD) contrast and bigger spectroscopy chemical shift, especially for human neuroimaging.
The commonly known issues associated with UHF MRI such as high-power deposition
and increase of specific absorption rate (SAR) and the inhomogeneity of the distribution of
circularly polarized time-varying magnetic field are currently being approached in many ways by
researchers across the world. This work contributes with the development of tools for
radiofrequency (RF) coil development capable of accelerating the development and design of RF
coils allowing creation of novel designs that otherwise would be impractical.
A new conformal head coil design is also presented as a next step towards fast and high-
resolution neuroimaging with high homogeneity and low power deposition. Using a conformal
Tic-Tac-Toe design and implementing novel excitation techniques simulated results were
acquiring showing a great potential for this design.
Acquisition and analysis of oscillations in the cerebrospinal fluid are shown here as a
potential biomarker for brain diseases specially Alzheimer’s disease. The results show a promising
methodology with consistent and reliable results that were acquired in volunteers.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Martins, Tiago Amarot.martins@pitt.edutia120000-0003-1582-9949
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairIbrahim, Tamer Stibrahim@pitt.edutsi20000-0001-6738-5855
Committee MemberAizenstein, Howard Jaizen@pitt.eduaizen
Committee MemberMettenburg, Josephmettenburgjm@upmc.edujmm318
Committee MemberStetten, George Dstetten@pitt.edustetten
Date: 6 September 2022
Date Type: Publication
Defense Date: 26 July 2022
Approval Date: 6 September 2022
Submission Date: 13 June 2022
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 130
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Bioengineering
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: mri, radiofrequency devices, coil, brain imaging
Date Deposited: 06 Sep 2022 16:32
Last Modified: 06 Sep 2022 16:32


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