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Layer-by-Layer Deposition and Silane SAMs: Thin Film Interactions with DNA Nanostructures

Smith, Jason (2022) Layer-by-Layer Deposition and Silane SAMs: Thin Film Interactions with DNA Nanostructures. Master's Thesis, University of Pittsburgh. (Unpublished)

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DNA molecules possess a variety of properties aside from genetics. These include
structural stability, programmability of sequences, and predictable self-assembly. Because of
these non-genetic properties, DNA nanotechnology has been studied and harnessed for a variety
of applications. These include X-ray crystallography, spectroscopy, medicine, therapeutics, and
machinery. Recently, many researchers have investigated how DNA nanostructures interact
with various materials. This research of DNA nanostructure-material interaction has been used
to develop a variety of applications. These applications include drug-delivery, biosensors,
electronics, and magnetic devices.
This thesis focuses on analyzing the interactive behavior of DNA origami nanostructures
with various materials, particularly thin films. Chapter one discusses the history and background
of DNA nanotechnology with a particular focus on DNA origami and the interaction between
DNA origami and thin films. Chapter two investigates the idea of growing inorganic materials
on top of DNA nanostructures using the thin film technique layer-by-layer deposition. This
chapter also discusses the history of layer-by-layer deposition along with the relationship it has
with DNA origami. The third chapter discusses the interactions between DNA nanostructures
and various organosilane self-assembled monolayers grown on SiO2 wafers. This chapter also
discusses the history of self-assembled monolayers (SAMs) and their relationship with DNA
origami. Ultimately, this thesis’ goal is to encourage future work regarding DNA nanostructures
and their interactions with various materials to further the endeavors of mankind.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Smith, JasonJTS101@pitt.eduJTS101@pitt.edu0000-0002-7574-5010
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairLiu,
Committee MemberLei,
Committee MemberMillstone,
Date: 12 October 2022
Date Type: Publication
Defense Date: 13 May 2022
Approval Date: 12 October 2022
Submission Date: 7 July 2022
Access Restriction: 1 year -- Restrict access to University of Pittsburgh for a period of 1 year.
Number of Pages: 118
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Self-assembled monolayers, DNA origami, Layer by Layer Deposition, Organosilanes, DNA nanotechnology
Date Deposited: 12 Oct 2022 20:39
Last Modified: 12 Oct 2023 05:15


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