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Low rate of rhesus immunization from rh- incompatible blood transfusions during liver and heart transplant surgery

Glenn, R and Linda, FH and Frank, WC and David, JB and Sandee, S and Roxann, C and Robert, LH and Bartley, PG and Thomas, ES (1989) Low rate of rhesus immunization from rh- incompatible blood transfusions during liver and heart transplant surgery. Transplantation, 47 (6). 993 - 995. ISSN 0041-1337

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Abstract

Transfusion of one unit or more of Rh-positive red blood cells normally causes circulating anti-D antibody to appear 2-6 months later in 80-95% of Rh persons. We asked whether transplant immunosuppression with cyclosporine and corticosteroids affects Rh immuniza¬tion. Nineteen Rh" liver, heart, and heart-lung transplant recipients received 3—153 (median: 10) units of Rh+ RBCs at surgery and were tested for anti-D > 2 months later. Three patients developed anti-D at 11—15 days; one may have had an unusually rapid primary immune response and two were secondary to previous exposure by pregnancy. None of the other 16 patients had anti-D when tested 2.5-51 months later (13 patients, > 11.5 months). This low rate of Rhesus immunization in association with cyclosporine immunosuppression allows greater flexibility in meeting the transfusion needs of Rh- liver and heart transplant patients. Caution is still advised in young females and in patients who may have been previously exposed to Rh+ RBCs by transfusion or by pregnancy prior to the availability of perinatal Rh immune globulin twenty years ago. Other humoral immune responses to some vaccines or infectious agents may also be impaired in transplant patients© 1989 by The Williams and Wilkins Co.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Glenn, R
Linda, FH
Frank, WC
David, JB
Sandee, S
Roxann, C
Robert, LH
Bartley, PG
Thomas, ES
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 47
Number: 6
Page Range: 993 - 995
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062130962, Starzl CV No. 947
Date Deposited: 08 Apr 2010 17:16
Last Modified: 13 Oct 2017 23:00
URI: http://d-scholarship.pitt.edu/id/eprint/4333

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