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Hepatic artery thrombosis after pediatric liver transplantation a medical or surgical event

Vincenzo, M and Carlos, E and Leonard, M and Steven, B and Delawir, K and Baburao, K and Velma, PS and Andrei, CS and Satoru, T and Andres, GT and Thomas, ES (1989) Hepatic artery thrombosis after pediatric liver transplantation a medical or surgical event. Transplantation, 47 (6). 971 - 977. ISSN 0041-1337

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Hepatic artery thrombosis (HAT) is one of the most serious complications after orthotopic liver transplan¬tation, and is associated with a high morbidity and mor¬tality. This study retrospectively reviewed 66 liver transplants in children under the age of 10 years during1 a year-long period at a single institution.;A, total of 28 perioperative variables were analyzed to identify responsible factors of HAT. Of the 66 children, 18 (26%) developed HAT within 15 days after the transplant (HAT group); 29 (42%) had an uneventful postoperative course (control group). To avoid the possible influence of other complications 19 patients were excluded. Of the variables compared between the 2 study groups, three surgical factors (diameter of the hepatic artery-- greater or less than 3 mm; type of arterial anastomosis—end-to-end versus the use of an iliac graft or aortic conduit; and number of times the anastomosis was redone--one versus more than one), were found to be significantly different (P<.05) between HAT and control groups. Two medical factors also were significantly different: the use of intraoperative transfusion of fresh frozen plasma (FFP) and the administration of postoperative prophylactic anticoagulant treatment. A heparin and dextran-40 protocol appeared to be effective in preventing HAT (P<.02). Moreover, after multivariate analysis, anticoagulation therapy was demonstrated to with poor hepatic artery flow. © 1989 by The Williams and Wilkins Co.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Vincenzo, M
Carlos, E
Leonard, M
Steven, B
Delawir, K
Baburao, K
Velma, PS
Andrei, CS
Satoru, T
Andres, GT
Thomas, ES
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 47
Number: 6
Page Range: 971 - 977
DOI or Unique Handle: 10.1097/00007890-198906000-00011
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062131002, Starzl CV No. 952
Date Deposited: 08 Apr 2010 17:16
Last Modified: 19 Jun 2020 14:55


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