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Effect of tamoxifen on hepatic regeneration in male rats

Kahn, D and Eagon, PK and Porter, LE and Elm, MS and Makowka, L and Podesta, L and Starzl, TE and Van Thiel, DH (1989) Effect of tamoxifen on hepatic regeneration in male rats. Digestive Diseases and Sciences, 34 (1). 27 - 32. ISSN 0163-2116

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Abstract

A number of metabolic changes within the liver occur concurrent with hepatic regeneration. These processes suggest that the administration of an antiestrogen might alter the rate of hepatic regeneration. To examine this question, male Wistar rats were treated with tamoxifen (0.1 mg/rat/day or 1.0 mg/rat/day) or vehicle for three days prior to and after partial hepatectomy, and the anatomic and biochemical process of hepatic regeneration was assessed. Tamoxifen administration caused a dose-dependent decrease in the hepatic cytosolic estrogen receptor activity and, conversely, a dose-dependent increase in cytosolic androgen receptor activity. Despite these changes in baseline hepatic sex steroid receptor status, all receptor activities were comparable between the three groups within 24 hr of partial hepatectomy. Moreover, no differences in any of the the parameters assessing hepatic regeneration following partial hepatectomy were evident: liver-body ratio, ornithine decarboxylase activity, and thymidine kinase activity. This lack of effect of tamoxifen treatment on hepatic regeneration suggests either that estrogens do not play a role in the modulation of liver growth after partial hepatectomy or that, once initiated, the regenerative process per se determines a series of events that regulate hepatocellular sex hormone receptor status independent of extrahepatic stimuli. © 1989 Plenum Publishing Corporation.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kahn, D
Eagon, PK
Porter, LE
Elm, MS
Makowka, L
Podesta, L
Starzl, TEtes11@pitt.eduTES11
Van Thiel, DH
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Digestive Diseases and Sciences
Volume: 34
Number: 1
Page Range: 27 - 32
DOI or Unique Handle: 10.1007/bf01536150
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0163-2116
Other ID: uls-drl:31735062131044, Starzl CV No. 957
Date Deposited: 08 Apr 2010 17:16
Last Modified: 13 Oct 2017 21:59
URI: http://d-scholarship.pitt.edu/id/eprint/4343

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