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Renal transplantation in baboons under FK 506

Todo, S and Demetris, A and Ueda, Y and Imventarza, O and Cadoff, E and Zeevi, A and Starzl, TE (1989) Renal transplantation in baboons under FK 506. Surgery, 106 (2). 444 - 451. ISSN 0039-6060

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Abstract

FK 506 was tested in unrelated baboons submitted to renal transplantation and bilateral native nephrectomy. Untreated baboons died after 9.2 ± 4.0 SD days. When FK 506 was given orally for 90 days, survival with the optimum dose was 74.6 ± 28.9 days; this allowed maximum credit for each individual animal of 90 days. A 3-day course of intramuscular FK 506 started on postoperative day 4 allowed 1- to 2-month survival. Delayed rejection in these baboons as well as in those treated daily for 90 days with FK could sometimes be reversed temporarily with a second 3-day course. The doses required for a good therapeutic effect were 10 times greater in baboons than in dogs, a finding that may reflect a species difference of lymphocyte sensitivity to this drug. FK appeared to be relatively nontoxic in subhuman primates, and it remains a promising drug for clinical trial. © 1989.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Todo, S
Demetris, A
Ueda, Y
Imventarza, O
Cadoff, E
Zeevi, A
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 106
Number: 2
Page Range: 444 - 451
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062131085, Starzl CV No. 961
Date Deposited: 08 Apr 2010 17:16
Last Modified: 14 Oct 2017 05:57
URI: http://d-scholarship.pitt.edu/id/eprint/4347

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