Todo, S and Demetris, A and Ueda, Y and Imventarza, O and Cadoff, E and Zeevi, A and Starzl, TE
(1989)
Renal transplantation in baboons under FK 506.
Surgery, 106 (2).
444 - 451.
ISSN 0039-6060
Abstract
FK 506 was tested in unrelated baboons submitted to renal transplantation and bilateral native nephrectomy. Untreated baboons died after 9.2 ± 4.0 SD days. When FK 506 was given orally for 90 days, survival with the optimum dose was 74.6 ± 28.9 days; this allowed maximum credit for each individual animal of 90 days. A 3-day course of intramuscular FK 506 started on postoperative day 4 allowed 1- to 2-month survival. Delayed rejection in these baboons as well as in those treated daily for 90 days with FK could sometimes be reversed temporarily with a second 3-day course. The doses required for a good therapeutic effect were 10 times greater in baboons than in dogs, a finding that may reflect a species difference of lymphocyte sensitivity to this drug. FK appeared to be relatively nontoxic in subhuman primates, and it remains a promising drug for clinical trial. © 1989.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Todo, S | | | | | Demetris, A | | | | | Ueda, Y | | | | | Imventarza, O | | | | | Cadoff, E | | | | | Zeevi, A | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 January 1989 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Surgery |
| Volume: |
106 |
| Number: |
2 |
| Page Range: |
444 - 451 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0039-6060 |
| Other ID: |
uls-drl:31735062131085, Starzl CV No. 961 |
| Date Deposited: |
08 Apr 2010 17:16 |
| Last Modified: |
04 Feb 2019 15:57 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/4347 |
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