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Hepatic artery thrombosis following pediatric liver transplantation: Assessment of blood flow measurement in allografts

Yanaga, K and Makowka, L and Shimada, M and Esquivel, CO and Bowman, JS and Todo, S and Tzakis, AG and Starzl, TE (1989) Hepatic artery thrombosis following pediatric liver transplantation: Assessment of blood flow measurement in allografts. Clinical Transplantation, 3 (4). 184 - 189. ISSN 0902-0063

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Abstract

The purpose of this study was to define parameters which could be predictive of hepatic artery thrombosis, which continues to be a major complicating factor in pediatric liver transplantation. The hepatic blood flow of 14 pediatric liver patients (15 grafts) who weighted less than 15 kg was measured electromagnetically during orthotopic liver transplantation. The results of blood flow determination and the clinical data in 7 patients (8 grafts) who developed hepatic artery thrombosis were compared with those of 7 control patients. All patients with a hepatic arterial flow of less than 60 ml/min developed hepatic artery thrombosis (4/8 vs. 0/7; p < 0.05), and the patients with hepatic artery thrombosis exhibited higher total hepatic and portal vein flow per 100 gram of liver tissue (262 vs. 136 ml/min; p < 0.001 and 222 vs. 80 ml/min; p < 0.025, respectively) as well as longer cold preservation time (384 vs. 326 min; p < 0.025). The results of our study suggest that hepatic arterial flows of less than 60 ml/min are critical for the development of hepatic artery thrombosis, and that portal venous overflow and increased preservation times may contribute to the development of hepatic artery thrombosis.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Yanaga, K
Makowka, L
Shimada, M
Esquivel, CO
Bowman, JS
Todo, S
Tzakis, AG
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Clinical Transplantation
Volume: 3
Number: 4
Page Range: 184 - 189
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0902-0063
Other ID: uls-drl:31735062122043, Starzl CV No. 976
Date Deposited: 08 Apr 2010 17:16
Last Modified: 02 Feb 2019 13:56
URI: http://d-scholarship.pitt.edu/id/eprint/4362

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