Mohebnasab, Maedeh and Eriksson, Oskar and Persson, Barbro and Sandholm, Kerstin and Mohlin, Camilla and Huber-Lang, Markus and Keating, Brendan J and Ekdahl, Kristina N and Nilsson, Bo
(2019)
Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics.
Front Immunol, 10.
2539 - ?.
Abstract
Aberrations in complement system functions have been identified as either direct or indirect pathophysiological mechanisms in many diseases and pathological conditions, such as infections, autoimmune diseases, inflammation, malignancies, and allogeneic transplantation. Currently available techniques to study complement include quantification of (a) individual complement components, (b) complement activation products, and (c) molecular mechanisms/function. An emerging area of major interest in translational studies aims to study and monitor patients on complement regulatory drugs for efficacy as well as adverse events. This area is progressing rapidly with several anti-complement therapeutics under development, in clinical trials, or already in clinical use. In this review, we summarized the appropriate indications, techniques, and interpretations of basic complement analyses, exemplified by a number of clinical disorders.
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Details
| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Mohebnasab, Maedeh | MAM1236@pitt.edu | MAM1236 | 0000-0001-6623-9514 | | Eriksson, Oskar | | | | | Persson, Barbro | | | | | Sandholm, Kerstin | | | | | Mohlin, Camilla | | | | | Huber-Lang, Markus | | | | | Keating, Brendan J | | | | | Ekdahl, Kristina N | | | | | Nilsson, Bo | | | |
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| Date: |
14 October 2019 |
| Date Type: |
Acceptance |
| Journal or Publication Title: |
Front Immunol |
| Volume: |
10 |
| Page Range: |
2539 - ? |
| DOI or Unique Handle: |
10.3389/fimmu.2019.02539 |
| Schools and Programs: |
School of Medicine > Pathology |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
CV%, clinical trial, functional assays, immunoassays, laboratory investigation, Clinical Trials as Topic, Complement Activation, Complement C1 Inhibitor Protein, Complement C5, Complement System Proteins, Humans, Receptors, Complement, Signal Transduction |
| Date Deposited: |
29 Aug 2022 17:09 |
| Last Modified: |
06 Sep 2022 13:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/43674 |
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