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Abdominal organ cluster transplantation for the treatment of upper abdominal malignancies

Starzl, TE and Todo, S and Tzakis, A and Podesta, L and Mieles, L and Demetris, A and Teperman, L and Selby, R and Stevenson, W and Stieber, A and Gordon, R and Iwatsuki, S (1989) Abdominal organ cluster transplantation for the treatment of upper abdominal malignancies. Annals of Surgery, 210 (3). 374 - 386. ISSN 0003-4932

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Ten patients with primary malignant tumors of the biliary tract, duodenum, or stomach and with secondary involvement of the liver underwent removal of most or all of the stomach, liver, pancreas, spleen, duodenum, proximal jejunum, terminal ileum, and ascending and transverse colon. The void in the upper abdomen was filled with an organ cluster graft consisting of the liver, pancreas, duodenum, and variable segments of proximal jejunum. Eight of the ten patients are alive after 3 to 9 months, all with good liver and pancreas function, and most with satisfactory function of the gastrointestinal tract. One of the surviving patients was in the hospital for 4 months because of multiple enteric fistulas and infections; the other seven survivors were discharged after an average of 43 ± 17.61 (SD) days. Recurrent tumor has not been proved in any of the surviving recipients and is suspected in only one. The study of such cases should provide insight and guidelines applicable to other visceral transplantation procedures that may be attempted in the future.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Todo, S
Tzakis, A
Podesta, L
Mieles, L
Demetris, A
Teperman, L
Selby, R
Stevenson, W
Stieber, A
Gordon, R
Iwatsuki, S
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Annals of Surgery
Volume: 210
Number: 3
Page Range: 374 - 386
DOI or Unique Handle: 10.1097/00000658-198909000-00013
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0003-4932
Other ID: uls-drl:31735062110295, Starzl CV No. 988
Date Deposited: 08 Apr 2010 17:16
Last Modified: 09 Dec 2017 12:55


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