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Comparison of UW with other solutions for liver preservation in dogs

Todo, S and Podesta, L and Ueda, Y and Imventarza, O and Cassavilla, A and Oks, A and Okuda, K and Nalesnik, M and Venkataramanan, R and Starzl, TE (1989) Comparison of UW with other solutions for liver preservation in dogs. Clinical Transplantation, 3 (5). 253 - 259. ISSN 0902-0063

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The efficacy of the University of Wisconsin (UW) solution was compared with conventional Euro-Collins solution, as well as with 3 variants of a silica gel solution developed at the University of Minnesota (UM). Protection of the liver grafts with UW was superior after 24 hour preservation, although the results were inferior to those with immediate transplantation, as judged by animal survival, liver function tests, coagulation, and histopathologic parameters. The UM-III solution allowed similar animal survival as with the UW solution. Lactobionate and raffinose that are contained in both the UW and UM-III solutions were thought to be essential constituents for long-term preservation of liver grafts. The study not only establishes, under controlled circumstances, the superiority of the UW solution, but it also provides insight about the reasons for its effectiveness as well as a caution against its over exploitation.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Todo, S
Podesta, L
Ueda, Y
Imventarza, O
Cassavilla, A
Oks, A
Okuda, K
Nalesnik, Mnalesnik@pitt.eduNALESNIK
Venkataramanan, Rrv@pitt.eduRV
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Clinical Transplantation
Volume: 3
Number: 5
Page Range: 253 - 259
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0902-0063
Other ID: uls-drl:31735062110444, Starzl CV No. 1003
Date Deposited: 08 Apr 2010 17:17
Last Modified: 29 Jan 2019 15:55


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