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Estradiol and testosterone levels in patients undergoing partial hepatectomy - A possible signal for hepatic regeneration?

Francavilla, A and Gavaler, JS and Makowka, L and Barone, M and Mazzaferro, V and Ambrosino, G and Iwatsuki, S and Guglielmi, FW and Dileo, A and Balestrazzi, A and Van Thiel, DH and Starzl, TE (1989) Estradiol and testosterone levels in patients undergoing partial hepatectomy - A possible signal for hepatic regeneration? Digestive Diseases and Sciences, 34 (6). 818 - 822. ISSN 0163-2116

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Abstract

In five adult male patients undergoing a 40-60% partial hepatectomy, serum sex hormone levels before and after hepatic resection were determined. Blood was drawn immediately prior to each surgical procedure and at specified time points postoperatively. Compared to hormone levels found prior to surgery, following major hepatic resection, estradiol levels increase at 24 and 48 hr, while testosterone levels decline, being significantly reduced at 96 and 144 hr. These data demonstrate that adult males who undergo a 40-60% partial hepatectomy experience alterations in their sex hormone levels similar to those observed in male rats following a 70% hepatectomy. These changes in sex hormone levels have been associated in animals with an alteration of the sex hormone receptor status of the liver that is thought to participate in the initiation of the regenerative response. These studies suggest, but do not prove, that in man, as in the case of the rat, sex hormones may participate in the initiation of or at least modulate in part the regenerative response that occurs following a major hepatic resection. © 1989 Plenum Publishing Corporation.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Francavilla, A
Gavaler, JS
Makowka, L
Barone, M
Mazzaferro, V
Ambrosino, G
Iwatsuki, S
Guglielmi, FW
Dileo, A
Balestrazzi, A
Van Thiel, DH
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 June 1989
Date Type: Publication
Journal or Publication Title: Digestive Diseases and Sciences
Volume: 34
Number: 6
Page Range: 818 - 822
DOI or Unique Handle: 10.1007/bf01540264
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0163-2116
Other ID: uls-drl:31735062110501, Starzl CV No. 1009
Date Deposited: 08 Apr 2010 17:17
Last Modified: 09 Dec 2017 12:55
URI: http://d-scholarship.pitt.edu/id/eprint/4395

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