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The Acceptance of Free-Floating Biomarker Concentration as a Validated Measurement of Sleep Deprivation Related Endothelial Function in Shift Workers: A Narrative Literature Review

Roach, David G.L. (2023) The Acceptance of Free-Floating Biomarker Concentration as a Validated Measurement of Sleep Deprivation Related Endothelial Function in Shift Workers: A Narrative Literature Review. Master Essay, University of Pittsburgh.

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Cardiovascular Disease (CVD) is the leading cause of all-cause mortality globally and in the United States. The endothelium is a monolayer of cells that constitutes the innermost lining of the vascular system and helps to regulate blood fluidity, clotting, and numerous other functions. Sleep deprivation is a common aspect of performing shift work and rotating shift work. Previous studies have assessed the possible effect of sleep deprivation on reducing endothelial function. The objective of this narrative literature review was to examine what exists in the literature regarding the acceptance of measuring concentrations of biomarkers such as syndecan-1, thrombomodulin, and vascular endothelial growth factor (VEGF) as validated pre-clinical measures of endothelial function compared to the gold standard and whether measures of endothelial dysfunction could detect a difference between the endothelial function of shift vs. non-shift workers. A search of Ovid Medline, Google Scholar, and SciWheel using MeSH terms and keywords representing the concepts of cardiovascular disease, biomarkers of endothelial function, endothelial dysfunction, circadian disruption, and shift work was conducted to identify relevant studies. After exclusion, 14 studies were reviewed and categorized by endothelial function test used and outcome assessed in the study. Two-thirds (66.6%) of the included studies focusing on measurement of endothelial function through Peripheral Arterial Tone (PAT), Flow Mediated Dilation (FMD), or Forearm Blood Flow (FBF) found a moderately positive association between measurement method and exposure to shift work or total sleep deprivation. Most studies assessing the concentration of free-floating biomarkers found a moderately positive association between a measured increase in concentration of thrombomodulin, VEGF, thromboxane, ICAM, E-Selectin, and IL-6, and circadian rhythm, markers of systemic stress, and night shift work. The generalizability of these findings was hindered due to small, unrepresentative sample sizes in most studies suggesting possible associations. Future research should focus on completing randomized trials to assess the long-term effect that exposure to shift work has on endothelial function. The public health significance of this research lies in the global burden of CVD and the association between shift work and chronic illness.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Roach, David G.L.dgr21@pitt.edudgr21
ContributionContributors NameEmailPitt UsernameORCID
Thesis advisorGlynn, Nancy W.epidnwg@pitt.eduepidnwgUNSPECIFIED
Committee MemberPatterson, P. Danielpdp3@pitt.edupdp3UNSPECIFIED
Committee MemberPatel, Sanjay R.patelsr2@upmc.eduUNSPECIFIEDUNSPECIFIED
Date: 5 January 2023
Date Type: Completion
Submission Date: 13 December 2022
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 50
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Uncontrolled Keywords: None
Date Deposited: 05 Jan 2023 15:34
Last Modified: 05 Jan 2023 15:34


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