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A Two-Year Retrospective Analysis of Dual COVID-19 and Sepsis Infection Patients at UPMC McKeesport

Knight, Briana Mae (2023) A Two-Year Retrospective Analysis of Dual COVID-19 and Sepsis Infection Patients at UPMC McKeesport. Master Essay, University of Pittsburgh.

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Background: COVID-19 may be a new challenge requiring ongoing research, but sepsis has been a constant public health problem in hospitalized patients in the US. Literature reviews show the comparison and potential link between COVID-19 and viral sepsis. In this study, 13% of COVID-19 positive patients admitted to UPMC McKeesport over two-year span also developed concurrent sepsis. The goal of this study was to investigate the possible relationship between COVID-19 and sepsis and to determine prevention strategies to curb the severity of the dual infection.

Methods: Chart reviews were performed of patients with dual infection of COVID-19 and sepsis through electronic medical records. Data collected included: admit and discharge date, mortality, sex, language spoken, age, patient type, race, documented PCP, discharge disposition description, length of stay, vaccination status/type, and ventilator/intubation needs. Data was analyzed on Microsoft Excel and Stata 14.2.

Results: The mortality rate for patients with dual infection was 42%. Vaccinated mortality rate was 29% compared to unvaccinated mortality rate of 56%. There is a statistically significant difference between admission and discharge disposition when comparing patients who met Goal length of stay to Extreme length of stay. Vaccination status improved length of stay (LOS) outcome. Fully vaccinated patients had SSD of meeting Goal LOS compared to combined Medium and Extreme LOS (p=0.007).

Conclusion: The study results suggest a potential link between COVID-19 and sepsis, but future research with a larger sample size could provide further conclusions. Knowing if a link exists can lead to improved patient outcomes by identification of patients who could develop a dual infection.

Public Health Significance: COVID-19 and sepsis are very serious public health issues that burden hospital ICUs. It is important to study the link between the two diseases to target intervention and prevention measures and improve patient outcomes.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Knight, Briana Maebrk112@pitt.edubrk112
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairYassin, Mohamedyassinm@upmc.eduUNSPECIFIEDUNSPECIFIED
Committee MemberCowen, Clareedwardscm5@upmc.eduUNSPECIFIEDUNSPECIFIED
Committee MemberHa, Toantoan.ha@pitt.edutoan.haUNSPECIFIED
Date: 5 January 2023
Date Type: Completion
Number of Pages: 48
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Infectious Diseases and Microbiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Uncontrolled Keywords: COVID-19, sepsis, dual infection, severity, McKeesport, Infection Control
Date Deposited: 05 Jan 2023 14:34
Last Modified: 05 Jan 2023 14:34


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